PMID: 8609590Aug 1, 1995Paper

Melatonin counteracts lipid peroxidation induced by carbon tetrachloride but does not restore glucose-6 phosphatase activity

Journal of Pineal Research
W M DanielsG G Ortiz

Abstract

Carbon tetrachloride (CCl4) exerts its toxic effects by the generation of free radicals. In this study we investigated whether melatonin, a potent free radical scavenger, could prevent the deleterious effects of CCl4. Liver homogenates and liver microsomes were incubated with CCl4 in the presence of melatonin and lipid peroxidation and glucose-6 phosphatase (G6Pase) activity were determined. All doses of CCl4 (1, 0.5, 0.1 mM) produced significantly high levels of lipid peroxidation, as reflected by increased levels of malonaldehyde and 4-hydroxyalkenals, in both liver homogenates and liver microsomes. These doses of CCl4 concommitantly reduced the activity of microsomal G6Pase. Co-incubation with melatonin dose-dependently (2, 1, 0.5 mM) inhibited the production of lipid peroxidation, but it was unable to restore the activity of G6Pase. In in vivo studies, rats were also treated with melatonin (10 mg/kg, i.p.), given 30 min before and 60 min after the administration of CCl4 (5 ml/kg, i.p.). Significantly elevated levels of lipid peroxidation were measured in the liver and kidney. Melatonin prevented the CCl4-induced lipid peroxidation in the kidney, but not in the liver. These data suggest that melatonin may provide protection ...Continue Reading

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Citations

Feb 11, 2005·Journal of Physiology and Biochemistry·M OgeturkM Sarsilmaz
Oct 1, 1995·Aging : Clinical and Experimental Research·R J Reiter
Jan 1, 1996·Free Radical Biology & Medicine·K A MarshallB Halliwell
Jan 7, 1999·European Journal of Pharmacology·G CostantinoA P Caputi
Jan 1, 1997·Free Radical Biology & Medicine·M A LivreaM Morreale
Jan 16, 1999·Free Radical Biology & Medicine·F AntunesF Xi
May 23, 2001·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·M M Anwar, M A Moustafa
Nov 10, 2001·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·H X WangT B Ng
Jan 25, 2013·Gastroenterology Research and Practice·Cezary ChojnackiJan Chojnacki
Mar 27, 2010·Arhiv za higijenu rada i toksikologiju·Seema Sharma, Suresh Vir Singh Rana
Dec 25, 2010·World Journal of Gastroenterology : WJG·Alexander M Mathes
Jun 23, 2010·International Journal of Biological Sciences·Walid M Al-GhoulNadeem Fazal
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Jan 26, 2016·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Eduardo Esteban-ZuberoRussel J Reiter
Aug 26, 2006·Drug and Chemical Toxicology·Sudipta Pal, Ajay K Chatterjee
Feb 19, 1998·Journal of Pineal Research·L M Finocchiaro, G C Glikin
Mar 24, 1998·Journal of Pineal Research·W M DanielsJ J Taljaard
May 1, 1997·Journal of Pineal Research·M R Kelly, G Loo
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Jan 26, 2010·Journal of Ethnopharmacology·Rahmat Ali KhanSumaira Sahreen
May 12, 2015·Journal of Pineal Research·Beatriz San-MiguelJavier González-Gallego
Oct 30, 2004·Cell Biochemistry and Function·L B ZavodnikR J Reiter
Sep 24, 2004·Cell Biochemistry and Function·Murat OgeturkMustafa Sarsilmaz
Apr 1, 2008·Journal of Pineal Research·F Larios-ArceoS Rodríguez-Reynoso
Feb 28, 2006·Journal of Pineal Research·Fragiska SigalaIoanna Andreadou
Nov 24, 2011·Journal of Pineal Research·Sergio A Rosales-CorralRussel J Reiter

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