Melatonin: Countering Chaotic Time Cues

Frontiers in Endocrinology
Josephine Arendt

Abstract

Last year melatonin was 60 years old, or at least its discovery was 60 years ago. The molecule itself may well be almost as old as life itself. So it is time to take yet another perspective on our understanding of its functions, effects and clinical uses. This is not a formal review-there is already a multitude of systematic reviews, narrative reviews, meta-analyses and even reviews of reviews. In view of the extraordinary variety of effects attributed to melatonin in the last 25 years, it is more of an attempt to sort out some areas where a consensus opinion exists, and where placebo controlled, randomized, clinical trials have confirmed early observations on therapeutic uses. The current upsurge of concern about the multiple health problems associated with disturbed circadian rhythms has generated interest in related therapeutic interventions, of which melatonin is one. The present text will consider the physiological role of endogenous melatonin, and the mostly pharmacological effects of exogenous treatment, on the assumption that normal circulating concentrations represent endogenous pineal production. It will concentrate mainly on the most researched, and accepted area of therapeutic use and potential use of melatonin-its ...Continue Reading

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Jun 11, 2020·Archives of Physiology and Biochemistry·Saptadip Samanta
Jul 1, 2020·Journal of Pineal Research·Somanathapura K NaveenKumarKesturu S Girish
Jul 30, 2020·Breastfeeding Medicine : the Official Journal of the Academy of Breastfeeding Medicine·Sonia Aparici-GonzaloPilar Codoñer-Franch
May 10, 2020·Interface Focus·Gaby Illingworth
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Oct 28, 2020·Journal of Pineal Research·Jean A Boutin, Ralf Jockers
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Sep 24, 2021·Neuropsychopharmacology Reports·Taro KishiNakao Iwata

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