Melatonin effect on bone metabolism in rats treated with methylprednisolone

Journal of Pineal Research
Marta G LadizeskyDaniel P Cardinali

Abstract

The present study was undertaken to examine the effect of melatonin (25 microg/mL of drinking water, about 500 microg/day) on a 10-wk long treatment of male rats with methylprednisolone (5 mg/kg s.c., 5 days/wk). Bone densitometry and mechanical properties, calcemia, phosphatemia and serum bone alkaline phosphatase activity and C-telopeptide fragments of collagen type I (CTX) were measured. Both melatonin and methylprednisolone decreased significantly body weight (BW) and the combination of both treatments resulted in the lowest BW values found. Consequently, all results were analyzed with BW as a covariate. Densitometrically, methylprednisolone augmented bone mineral content (BMC), bone area (BA) and bone mineral density (BMD) in the entire skeleton, BMC in cortical bone, and BMC and BMD in trabecular bone. Melatonin increased BMC and BA in whole skeleton and BMC and BMD in trabecular bone. For BMC and BA of whole skeleton, BMC of cortical bone, and BMC and BMD of trabecular bone, the combination of glucocorticoids and melatonin resulted in the highest values observed. Femoral weight of rats receiving methylprednisolone or melatonin increased significantly and both treatments summated to achieve the greatest effect. In femoral...Continue Reading

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Citations

Feb 11, 2012·Clinical Oral Investigations·María Piedad Ramírez-FernándezMiguel Alcaraz-Baños
Mar 13, 2014·Rejuvenation Research·Isabel F TresguerresJesús A F Tresguerres
Jul 5, 2006·The FEBS Journal·S R Pandi-PerumalR Hardeland
May 15, 2013·International Journal of Molecular Sciences·Jie LiuHong-Wen He
Sep 23, 2014·International Journal of Molecular Sciences·Gene Chi Wai ManCheng Jack Chun Yiu
Dec 2, 2017·Fundamental & Clinical Pharmacology·Majid GhareghaniNaser Farhadi
Jan 1, 2019·Journal of Pineal Research·Tian LiYang Yang
Apr 13, 2011·Journal of Pineal Research·Gene Chi-Wai ManJack Chun-Yiu Cheng
Jul 17, 2021·Acta Biomaterialia·Xiangbing WuHongchang Lai

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