Melatonin-enhanced hyperactivation of hamster sperm

Reproduction : the Official Journal of the Society for the Study of Fertility
Masakatsu Fujinoki

Abstract

The effects of melatonin on reproductive function were examined using hamster spermatozoa. When 1 pM to 1 microM melatonin was added to the mTALP medium, hyperactivation was significantly enhanced. Antagonists and agonists of the melatonin receptor (i.e., MT1 and MT2) were added to the medium. Luzindole, an MT1 and MT2 competitive antagonist, significantly inhibited melatonin-induced hyperactivation, whereas the MT2-specific antagonists, 4-phenyl-2-propionamidotetralin and N-pentanoyl-2-benzyltryptamine, had no effect. Moreover, hyperactivation was significantly enhanced when non-specific agonists, such as 6-chloromelatonin and 2-iodomelatonin, were added to the medium. 8-Methoxy-2-propionamidotetralin, which is a strong MT2 agonist and a weak MT1 agonist, significantly increased hyperactivation, although the effect was weak. Therefore, it is likely that melatonin enhances sperm hyperactivation via the MT1 receptor.

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Citations

May 15, 2013·Animal Reproduction Science·Iraj AshrafiFarhad Farrokhi Ardabili
Sep 1, 2012·Reproduction, Fertility, and Development·Adriana CasaoJosé Álvaro Cebrián-Pérez
Feb 25, 2014·Animal Reproduction Science·Maria Helena Coelho CruzRussel J Reiter
May 11, 2011·Reproduction : the Official Journal of the Society for the Study of Fertility·Masakatsu Fujinoki
Jun 22, 2010·Reproduction : the Official Journal of the Society for the Study of Fertility·Masakatsu Fujinoki
Feb 16, 2010·Fertility and Sterility·Javier EspinoAna B Rodríguez
May 12, 2015·The Journal of Reproduction and Development·Masakatsu Fujinoki, Gen L Takei
Apr 14, 2011·Journal of Pineal Research·Carolina M Balao da SilvaFernando J Peña
Jan 11, 2011·Journal of Pineal Research·Sara SuccuSalvatore Naitana
Oct 4, 2014·Reproduction in Domestic Animals = Zuchthygiene·J A Cebrián-PérezT Muiño-Blanco
Nov 19, 2009·Journal of Pineal Research·Adriana CasaoTeresa Muino-Blanco
Sep 5, 2014·Journal of Pineal Research·Ignacio BejaranoJavier Espino
Nov 7, 2015·The Journal of Physiological Sciences : JPS·Masakatsu FujinokiHiroe Kon
Dec 18, 2014·Reproduction, Fertility, and Development·Marta Gonzalez-ArtoAdriana Casao
Jun 28, 2016·Cell and Tissue Banking·Fardin AmidiSaeid Nekoonam
Mar 31, 2015·International Journal of Immunopathology and Pharmacology·M H KarimfarSalar Bakhtiyari
Oct 25, 2016·The Journal of Reproduction and Development·Masakatsu Fujinoki, Gen L Takei
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Sep 1, 2013·Balsaeng'gwa saengsig·Donchan Choi
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Apr 4, 2013·International Journal of Molecular Sciences·Russel J ReiterDun-Xian Tan
Sep 14, 2018·Reproduction, Fertility, and Development·Silvia Gimeno-MartosRosaura Pérez-Pé
Jul 11, 2020·Reproduction in Domestic Animals = Zuchthygiene·Yi FangRongzhen Zhong
Mar 13, 2014·The Journal of Reproduction and Development·Hiroe KonMotoo Shinoda
May 24, 2020·Tropical Animal Health and Production·Melissa Carvajal-SernaAdriana Casao
Sep 12, 2012·Reproductive Medicine and Biology·Masakatsu Fujinoki
Apr 17, 2020·International Journal of Molecular Sciences·Estela Fernández-AlegreFelipe Martínez-Pastor
Nov 7, 2019·The Journal of Reproduction and Development·Yukiko SugiyamaHiroaki Shibahara
Apr 23, 2009·Reproductive Medicine and Biology·Masakatsu Fujinoki
Mar 10, 2016·Reproduction : the Official Journal of the Society for the Study of Fertility·Gen L Takei, Masakatsu Fujinoki
Jul 3, 2021·Animals : an Open Access Journal From MDPI·Melissa Carvajal-SernaRosaura Pérez-Pe
Aug 7, 2021·Antioxidants·Miguel A SilvestreMaría Castelló-Ruiz
May 14, 2021·The Journal of Reproduction and Development·Chiyori SakamotoSatoshi Obayashi

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