PMID: 9181519Mar 1, 1997Paper

Melatonin enhances cortisol levels in aged women: reversible by estrogens

Journal of Pineal Research
A CagnacciS S Yen

Abstract

The administration of melatonin increases cortisol levels in postmenopausal women. Aging and hypoestrogenism are believed to impair the regulation of the hypothalamo-pituitary-adrenal axis and may participate in the determination of this altered response. In this study the implications of hypoestrogenism were tested. Seven postmenopausal women were studied. At 08.00 hr for 2 consecutive days, each woman received randomly and in a double blind fashion a pill of placebo or melatonin (100 mg). Serum melatonin and cortisol levels were evaluated at 20 min intervals, for 48 hr. Measurements were performed in the same subjects both during no estrogen supplementation and at least two cycles of conjugated estrogens administration (0.625 mg/day). During estrogen supplementation, postmenopausal women showed slightly lower cortisol levels at lunch and early night (20.00-01.00 hr). The onset of the nocturnal melatonin rise was not modified, but that of cortisol was delayed of about 60 min (P < 0.02). The administration of melatonin elicited a marked increase in daytime cortisol levels in postmenopausal women (P < 0.02), but this stimulus completely disappeared during estrogen administration. Mean nighttime (20.00-08.00 hr) cortisol levels w...Continue Reading

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Citations

Feb 20, 2002·Journal of Advanced Nursing·R DeaneD Prashad
Jun 1, 1996·Journal of Endocrinological Investigation·A Cagnacci, A Volpe
Jan 1, 1997·Aging : Clinical and Experimental Research·A CagnacciA Volpe
Nov 11, 2005·Journal of Neuroendocrinology·B PerrasJ Born
Jun 12, 2010·Journal of Pineal Research·Alberto Dominguez-RodriguezRussel J Reiter
Nov 3, 2010·Menopause : the Journal of the North American Menopause Society·Angelo CagnacciAnnibale Volpe
Dec 1, 2006·Human Reproduction Update·Andrea Riccardo GenazzaniMichele Luisi
Jul 18, 2002·Journal of Pineal Research·Angelo CagnacciAnnibale Volpe
May 24, 2005·CNS Spectrums·Andrea Riccardo GenazzaniMichele Luisi
May 11, 2021·Journal of Pineal Research·Yulia Treister-Goltzman, Roni Peleg

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