PMID: 9551850Apr 29, 1998Paper

Melatonin excretion is not related to sleep in the elderly

Journal of Pineal Research
S D YoungstedtJ A Elliott

Abstract

We examined the association between 6-sulphatoxymelatonin (6-SMT) excretion and sleep in 68 volunteers 60-79 years of age who complained of insomnia or depression. An Actillume wrist monitor was worn for 5-7 consecutive days and nights in home-living conditions. Activity was used to estimate total sleep time (TST) and wake after sleep onset (WASO). Throughout two 24 hr periods, urine was collected approximately every 2 hr during the day and after any voidings during the sleep period. During the next week, subjects spent 5 nights and 4 days in the laboratory. Sleep was measured and scored with standard polysomnographic techniques. Urine was collected, as for home recording, on days 1 and 4. Urinary concentrations of 6-SMT were assayed. Cosine-fitting of urine data across both days at home and both laboratory collections established the mesors and amplitudes of 24 hr 6-SMT excretion rhythms, but neither was significantly correlated with sleep. Mean and peak 6-SMT excretion during the sleep period was also determined. Significant correlations were found between mean 6-SMT during the laboratory sleep period and TST and WASO. However, these associations were not independent of circadian timing: sleep was better when sleep occurred n...Continue Reading

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Citations

Oct 29, 2002·Brain, Behavior, and Immunity·Michael Irwin
Feb 28, 2001·Sleep Medicine·B Phillips, S Ancoli-Israel
Jun 18, 2002·Ageing Research Reviews·S R Pandi-PerumalD F Swaab
Jan 5, 2006·Behavioral Sleep Medicine·H Heith Durrence, Kenneth L Lichstein
Mar 21, 2007·Sleep Medicine·Eus J W Van Someren
Aug 2, 2003·Journal of the American Geriatrics Society·In-Young YoonRichard L Hauger
Mar 8, 2003·Journal of Neuroendocrinology·C CajochenA Wirz-Justice
Sep 27, 2005·Neurobiology of Aging·Mirjam MünchChristian Cajochen
Jul 16, 2013·Maturitas·Marcello MaggioGian Paolo Ceda
Dec 29, 2007·Journal of Korean Medical Science·Doo Heum ParkRobert D Langer
Feb 21, 2019·The Journal of Physiology·Shawn D YoungstedtDaniel F Kripke
Jan 30, 2021·Military Medicine·Shawn D YoungstedtSeungYong Han

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