Melatonin improves endothelial function in vitro and prolongs pregnancy in women with early-onset preeclampsia

Journal of Pineal Research
Sebastian R HobsonEuan M Wallace

Abstract

Preeclampsia remains a leading cause of maternal and perinatal morbidity and mortality. There have been no material advances in the treatment of preeclampsia for nearly 50 years. Combining in vitro studies and a clinical trial, we aimed to determine whether melatonin could be a useful adjuvant therapy. In a xanthine/xanthine oxidase (X/XO) placental explant model, melatonin reduced oxidative stress (8-isoprostane) and enhanced antioxidant markers (Nrf2 translocation, HO-1), but did not affect explant production of anti-angiogenic factors (sFlt, sEng, activin A). In cultured HUVECs, melatonin mitigated TNFα-induced vascular cell adhesion molecule expression and rescued the subsequent disruption to endothelial monolayer integrity but did not affect other markers for endothelial activation and dysfunction. In a phase I trial of melatonin in 20 women with preeclampsia, we assessed the safety and efficacy of melatonin on (i) preeclampsia progression, (ii) clinical outcomes, and (iii) oxidative stress, matching outcomes with recent historical controls receiving similar care. Melatonin therapy was safe for mothers and their fetuses. Compared to controls, melatonin administration extended the mean ± SEM diagnosis to delivery interval b...Continue Reading

References

Jan 1, 1991·Journal of Cardiovascular Pharmacology·K W FlorijnM A Schalekamp
Sep 1, 1990·American Journal of Obstetrics and Gynecology·B M SibaiM Moretti
May 1, 1993·Journal of Pineal Research·L I KornblihttF C Molinas
Jan 1, 1997·European Journal of Obstetrics, Gynecology, and Reproductive Biology·R AustgulenC W Redman
Dec 10, 1997·Journal of Pineal Research·C A De La LastraM J Martin
Sep 24, 1998·Journal of Pineal Research·Y OkataniY Sagara
Sep 24, 1998·Journal of Pineal Research·D X TanG H El-Sokkary
Nov 4, 2000·Journal of Biomedical Science·R J ReiterE Gitto
May 11, 2002·BMC Gastroenterology·Makoto SasakiSteven J Alexander
Mar 8, 2003·Journal of Neuroendocrinology·C CajochenA Wirz-Justice
Apr 2, 2003·Cardiovascular Research·Russel J Reiter, Dun-Xian Tan
Aug 28, 2003·Journal of Sleep Research·Naomi L RogersDrew Dawson
Feb 7, 2004·The New England Journal of Medicine·Richard J LevineS Ananth Karumanchi
Jul 7, 2005·Antioxidants & Redox Signaling·Antje Banning, Regina Brigelius-Flohé
May 9, 2006·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Kosuke KaidaKenji Fukasawa
Mar 3, 2007·The Journal of Endocrinology·Stephen MandangEuan M Wallace
Mar 14, 2007·Journal of Pineal Research·Silvia Jimenez-JorgePatrocinio Molinero
Apr 5, 2007·Nature Protocols·Bruno BaudinMichel Vaubourdolle
Mar 4, 2008·Journal of Pineal Research·Dave LanoixCathy Vaillancourt
Apr 22, 2008·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Wellington P MartinsFrancisco Mauad Filho
Mar 7, 2009·American Journal of Hypertension·Jason P BridgesJoey P Granger
Jul 6, 2010·Lancet·Eric A P SteegersRobert Pijnenborg
Oct 30, 2010·Ultrasound in Medicine & Biology·Jailson C LimaFrancisco Mauad Filho
Jan 5, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nurit HadadRachel Levy
Mar 2, 2011·Journal of Pineal Research·Hua WangDe-Xiang Xu
Jun 17, 2011·American Journal of Hypertension·Eric M George, Joey P Granger
Mar 2, 2012·Neuroendocrinology·S L MillerD W Walker

❮ Previous
Next ❯

Citations

Aug 10, 2018·Journal of Pineal Research·Lucas Sagrillo-FagundesCathy Vaillancourt
Feb 2, 2019·Expert Opinion on Pharmacotherapy·Annie G CoxEuan M Wallace
Dec 18, 2018·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Sarah A MarshallEuan M Wallace
Dec 13, 2019·Journal of Receptor and Signal Transduction Research·Yunpeng TianHaoming Song
Oct 20, 2019·Journal of Clinical Laboratory Analysis·Luyan ZhangGuomei Cao
Apr 7, 2020·Hypertension·Kathryn L GatfordAlison S Care
Aug 15, 2020·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Oğuzhan DoğanlarMetehan Uzun
Aug 30, 2019·Journal of Receptor and Signal Transduction Research·Long BaoZhixiong Lin
Oct 2, 2019·Frontiers in Endocrinology·Ronald McCarthySarah K England
Nov 23, 2019·Journal of Receptor and Signal Transduction Research·Guanqun Ma, Yingwu Liu
Sep 20, 2018·International Journal of Molecular Sciences·Gianfranco CarlomagnoVittorio Unfer
Feb 23, 2019·Frontiers in Endocrinology·Atul MalhotraSuzanne L Miller
Jan 8, 2020·International Journal of Molecular Sciences·Luiz Gustavo de Almeida ChuffaFábio Rodrigues Ferreira Seiva
Mar 27, 2020·Frontiers in Endocrinology·James M Olcese
Oct 30, 2019·Journal of Receptor and Signal Transduction Research·Xinyu Song, Tianchang Li
Dec 28, 2018·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Delia I ChiarelloReinaldo Marín
Apr 4, 2021·Antioxidants·Annie Langston-CoxEuan M Wallace
Apr 4, 2021·Antioxidants·Xiang-Qun Hu, Lubo Zhang
Apr 9, 2021·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Wang JingYangYu Zhao
Aug 28, 2021·Frontiers in Cell and Developmental Biology·Xudong WangZiji Zhang
Sep 2, 2021·American Journal of Reproductive Immunology : AJRI·Ourlad Alzeus G TantengcoRamkumar Menon
Oct 30, 2021·Current Medical Research and Opinion·David J Kennaway

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.