PMID: 9547159Apr 18, 1998Paper

Melatonin induces hyporeactivity caused by type II collagen in peripheral blood lymphocytes from patients with autoimmune hearing losses

Neuroscience Letters
M A Lopez-GonzalezF Delgado

Abstract

We have studied the behavior of peripheral blood lymphocytes in healthy controls and in patients with various hearing losses. These hearing losses were of an autoimmune origin in which type II collagen and melatonin were either present or absent, activated or not with concanavalin A (Con A). In patients with autoimmune hearing losses, the results showed lymphocytes that displayed hyporeactivity to type II collagen in terms of their proliferative activity in the presence of Con A. The hyporeactivity is specially relevant in those cells which are melatonin incubated. When different nosologic entities were studied, we observed similar lymphocyte hyporeactivity to type II collagen in bilateral sensorineural hearing loss, Ménière's disease and otosclerosis. We conclude that in the lymphocytes of patients with autoimmune hearing losses, there is hyporeactivity to type II collagen when compared to the hyporeactivity of lymphocytes in control groups. This hyporeactivity is revealed when the lymphocytes are activated in the presence of melatonin.

References

Sep 1, 1979·The Annals of Otology, Rhinology, and Laryngology·B F McCabe
Jul 1, 1992·Journal of Neuroimmunology·I HanssonR Mattsson
Aug 1, 1994·The Journal of Experimental Medicine·E MichaëlssonR Holmdahl

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Citations

Apr 24, 2013·International Journal of Molecular Sciences·Antonio Carrillo-VicoJuan M Guerrero
Aug 7, 2013·Rejuvenation Research·Hong Miao RenWei Liu

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