Melatonin influences the sonic hedgehog signaling pathway in porcine cumulus oocyte complexes

Journal of Pineal Research
Sanghoon LeeByeong-Chun Lee

Abstract

Melatonin, which is synthesized in the pineal gland and peripheral reproductive organs, has antioxidant properties and regulates physiological processes. It is well known that melatonin affects in vitro maturation (IVM) of oocytes and embryonic development in many species. However, beneficial effects of melatonin on IVM have been explained mainly by indirect antioxidant effects and little information is available on the underlying mechanism by which melatonin directly acts on porcine cumulus oocyte complexes (COCs). Sonic hedgehog (Shh) signaling is important for follicle development, oocyte maturation, and embryo development, and there may be a relationship between melatonin and Shh signaling. To examine this, we designed three groups: (i) control, (ii) melatonin (10-9  mol/L), and (iii) melatonin with cyclopamine (2 μmol/L; Shh signaling inhibitor). The aim of this study was to investigate the effects of these agents on cumulus expansion, oocyte maturation, embryo development after parthenogenetic activation (PA), gene expression in cumulus cells, oocytes and blastocysts, and protein expression in COCs. Melatonin significantly increased the proportion of COCs exhibiting complete cumulus expansion (degree 4), PA blastocyst for...Continue Reading

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Citations

Feb 14, 2019·Annals of the New York Academy of Sciences·Mayuri ShuklaRussel J Reiter
Jun 5, 2018·International Journal of Molecular Sciences·Sanghoon LeeByeong-Chun Lee
Apr 14, 2019·Reproductive Biology and Endocrinology : RB&E·Yiran LiYingpu Sun
May 28, 2020·International Journal of Molecular Sciences·Pil-Soo JeongSun-Uk Kim
Feb 13, 2020·International Journal of Molecular Sciences·Hiroshi TamuraNorihiro Sugino
Dec 9, 2020·The Science of the Total Environment·Sanghoon LeeSun-Uk Kim
Apr 18, 2021·Molecular and Cellular Biochemistry·Maryam EzzatiRaziyeh Kheirjou

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