Melatonin inhibits amphetamine-induced increase in alpha-synuclein and decrease in phosphorylated tyrosine hydroxylase in SK-N-SH cells

Neuroscience Letters
Sirirat KlongpanichapakPiyarat Govitrapong

Abstract

alpha-Synuclein is an abundant presynaptic protein implicated in neuronal plasticity and neurodegeneration disorders. Understanding alpha-synuclein function in dopaminergic cells could add to our knowledge of this key protein which is implicated in Parkinson's disease. Chronic or intermittent amphetamine (AMPH) abuse may create temporary or permanent disturbances in the dopaminergic system of the brain that may predispose individuals to Parkinsonism. Our previous studies showed that neurotoxicity induced by AMPH was mediated by enhanced oxidative stress and these effects were abolished by melatonin, a main secretory product of pineal gland. The present study was conducted to investigate the effect of AMPH on alpha-synuclein in regulating tyrosine hydroxylase (TH), a rate limiting enzyme for dopamine synthesis, in cultured human dopaminergic SK-N-SH cells. Of these, phosphorylation of Ser40 (pSer40) contributes significantly to TH activation and dopamine synthesis. Our data indicated that AMPH significantly increased the level of alpha-synuclein to 183% of the control value while reducing the levels of phosphorylated TH (TH-pSer40) enzyme and mitochondrial complex I to 78 and 52.9% of the control values, respectively and these e...Continue Reading

References

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Jul 7, 2007·Journal of Pineal Research·Sirirat KlongpanichapakPiyarat Govitrapong

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Citations

Sep 3, 2013·Toxicological Sciences : an Official Journal of the Society of Toxicology·Aracely Garcia-GarciaRodrigo Franco
Aug 27, 2013·Neurotoxicity Research·Pichaya JumnongprakhonJiraporn Tocharus
Sep 24, 2014·International Journal of Molecular Sciences·Anorut JenwitheesukPiyarat Govitrapong
Sep 24, 2011·The International Journal of Neuropsychopharmacology·Hua TanJun-Feng Wang
Mar 7, 2012·Hormones and Behavior·Daniel P CardinaliPablo Scacchi
Nov 11, 2016·Oxidative Medicine and Cellular Longevity·Josiel Mileno MackRui Daniel Prediger
Jul 29, 2010·Journal of Pineal Research·Areechun SotthibundhuPiyarat Govitrapong
Aug 27, 2010·Journal of Pineal Research·Chutikorn NopparatPiyarat Govitrapong
Feb 5, 2019·Journal of Neurochemistry·Peter R Dunkley, Phillip W Dickson
Mar 27, 2015·Journal of Korean Neurosurgical Society·Murat TosunHamit Selim Karabekir
Mar 23, 2018·Journal of Alzheimer's Disease : JAD·Abhishek Ankur Balmik, Subashchandrabose Chinnathambi
Aug 10, 2017·Cellular and Molecular Life Sciences : CMLS·Pawaris Wongprayoon, Piyarat Govitrapong
Aug 6, 2019·Frontiers in Endocrinology·Daniel P Cardinali

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Alpha-synucleins are small proteins that are believed to restrict the mobility of synpatic vesicles and inhibit neurotransmitter release. Aggregation of these proteins have been linked to several types of neurodegenerative diseases including dementia with Lewy bodies and Parkinson's disease. Here is the latest research on α-synuclein aggregation.