Melatonin inhibits arsenite-induced peripheral neurotoxicity

Journal of Pineal Research
Anya Maan-Yuh LinC H Yang

Abstract

In this study, the effect of melatonin on sodium arsenite (arsenite)-induced peripheral neurotoxicity was investigated using dorsal root ganglion (DRG) explants. After 24-hr incubation, arsenite (30 microm) consistently elevated the expression of heat shock protein 70 and haeme oxygenase-1, two well-known stress proteins, in the treated DRG explants. Co-incubation with melatonin (4 and 20 mm) concentration-dependently attenuated arsenite-induced elevation in stress proteins. Furthermore, melatonin inhibited arsenite-induced phosphorylation of p38 and DNA fragmentation. Inhibition by melatonin of arsenite-induced apoptosis was mediated via inactivating both endoplasmic reticulum (ER) and mitochondrial pathways. In the ER pathway, melatonin suppressed arsenite-induced elevation in activating transcription factor-6 and CCAAT/enhancer-binding protein homologous protein in the nuclear fraction of the treated DRG explants. Moreover, melatonin attenuated arsenite-induced activation of caspase 12, an ER-specific enzyme. In the mitochondrial pathway, arsenite-induced increases in Bcl-2 levels and cytosolic cytochrome c were reduced by melatonin. At the same time, melatonin inhibited arsenite-induced activation of caspase 3 in the treate...Continue Reading

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Citations

Jul 14, 2012·International Journal of Dentistry·Murat İnanç CengizHom-Lay Wang
Jul 29, 2011·Journal of Pineal Research·Yan-Li JiDe-Xiang Xu
Jun 27, 2013·Journal of Gastroenterology and Hepatology·Tseng-Shing Chen, Full-Young Chang
Mar 19, 2014·Journal of Pineal Research·Alejandro RomeroRussel J Reiter
Jul 24, 2015·Journal of Pineal Research·Anna FernándezJosé L Mauriz
Feb 3, 2015·Toxicology Letters·Yu-Chun TengAnya Maan-Yuh Lin
Oct 21, 2016·British Journal of Pharmacology·Wei HuDongjin Wang
Jun 18, 2020·Cancers·Sangiliyandi GurunathanJin-Hoi Kim

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