Melatonin inhibits neuronal dysfunction-associated with neuroinflammation by atopic psychological stress in NC/Nga atopic-like mouse models

Journal of Pineal Research
Gunhyuk ParkYong-Ung Kim

Abstract

Atopic dermatitis (AD), also known as atopic eczema, is chronic pruritic skin disease. AD can increase psychological stress as well, increasing glucocorticoid release and exacerbating the associated symptoms. Chronic glucocorticoid elevation disturbs neuroendocrine signaling and can induce neuroinflammation, neurotoxicity, and cognitive impairment; however, it is unclear whether AD-related psychological stress elevates glucocorticoids enough to cause neuronal damage. Therefore, we assessed the effects of AD-induced stress in a mouse AD model. AD-related psychological stress increased astroglial and microglial activation, neuroinflammatory cytokine expression, and markers of neuronal loss. Notably, melatonin administration inhibited the development of skin lesions, scratching behavior, and serum IgE levels in the model mice, and additionally caused a significant reduction in corticotropin-releasing hormone responsiveness, and a significant reduction in neuronal damage. Finally, we produced similar results in a corticosterone-induced AD-like skin model. This is the first study to demonstrate that AD-related psychological stress increases neuroendocrine dysfunction, exacerbates neuroinflammation, and potentially accelerates other ...Continue Reading

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Citations

Oct 13, 2017·International Journal of Molecular Sciences·Tzu-Kai LinJuan Luis Santiago
Feb 14, 2019·Annals of the New York Academy of Sciences·Mayuri ShuklaRussel J Reiter
Jun 15, 2019·Chronobiology International·David J Kennaway
Apr 14, 2020·Journal of Pineal Research·David J Kennaway
Dec 21, 2017·Journal of Neurovirology·Jianlin HeSulie L Chang
Nov 28, 2019·Oxidative Medicine and Cellular Longevity·Hye-Sun LimGunhyuk Park
Oct 11, 2019·International Journal of Molecular Sciences·Iryna RusanovaGermaine Escames
Jul 28, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Ly Thi Huong NguyenHeung-Mook Shin
Mar 18, 2021·Journal of Cellular and Molecular Medicine·Gunhyuk ParkMoon-Ki Park

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