Melatonin inhibits the basal and TSH-stimulated mitotic activity of thyroid follicular cells in vivo and in organ culture

Journal of Pineal Research
A Lewiński, E Sewerynek

Abstract

The aim of the present study has been to examine the effect of melatonin, administered to mice as daily subcutaneous injections for a total of 10 days, on the mitotic activity of thyroid follicular cells (TFC). The colchicine metaphase-arrest technique was employed in the experiment. We found that melatonin (10 micrograms and/or 100 micrograms injection) decreased significantly the mean mitotic activity rate (MMAR) of TFC in both male and female mice. Moreover, melatonin totally suppressed the stimulatory effect of TSH on the MMAR of TFC in both sexes of mice. Furthermore, the effect of melatonin (5 X 10(-7) M) on the proliferation of TFC in the organ-cultured rat and mouse thyroid explants was investigated. It was found that melatonin almost totally suppressed the MMAR of TFC in organ culture. Moreover, melatonin blocked the stimulatory effect of TSH on the MMAR of TFC in both rat and mouse thyroid explants. N-acetylserotonin (NAc-5HT, 10(-6) M) also decreased the MMAR of cultured thyroid explants, but its effect was less expressed when compared to melatonin inhibition. The present data indicate that melatonin can exert its inhibitory effect on the proliferation of TFC directly at the thyroid level, since this pineal indoleami...Continue Reading

References

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Citations

Jan 1, 1992·Journal of Neural Transmission. General Section·C HaldarS Singh
Dec 31, 1991·Biochemical and Biophysical Research Communications·E Wajs, A Lewiński
Nov 7, 2016·Italian Journal of Pediatrics·Gabriella D'AngeloEloisa Gitto
Sep 30, 2017·PloS One·Jiunn-Diann LinChao-Wen Cheng
Nov 10, 2006·Cell Biochemistry and Function·Muaz Belviranli, Abdulkerim Kasim Baltaci
Jan 1, 1989·Journal of Pineal Research·E Sewerynek, A Lewiński
May 19, 2020·Chronobiology International·Natalia Kurhaluk, Halyna Tkachenko
Mar 6, 2021·Acta histochemica·Marjan Ghorbani-AnarkooliMohammad Hadi Bahadori
Oct 8, 1998·Life Sciences·R M SáinzC Rodríguez

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