Melatonin interacts with repeat domain of Tau to mediate disaggregation of paired helical filaments

doi:10.1016/j.bbagen.2019.129467

Melatonin interacts with repeat domain of Tau to mediate disaggregation of paired helical filaments

Biochimica Et Biophysica Acta. General Subjects

Nov 9, 2019

Abhishek Ankur BalmikSubashchandrabose Chinnathambi

PMID: 31715192

DOI: 10.1016/j.bbagen.2019.129467

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Abstract

Tau is the major neuronal protein involved in the stabilization of microtubule assembly. In Alzheimer's disease, Tau self assembles to form intracellular protein aggregates which are toxic to cells. Various methods have been tried and tested to restrain the aggregation of Tau. Most of t...read more

Mentioned in this Paper

Alzheimer's Disease

Antioxidants

Melatonin

Neurons

Pineal Gland

Platelet Aggregation Inhibitors

Spectrum Analysis

Tau Proteins

Intracellular

Neurohormones

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