Melatonin involvement in immunity and cancer

Biological Signals and Receptors
F FraschiniF Scaglione

Abstract

The most studied endocrine product of the pineal gland, melatonin, has been reported to be involved in the feedback between neuroendocrine and immune functions and to exert oncostatic action, at least in certain experimental conditions. Melatonin seems to be an integral part of the immune system, by exerting direct and/or indirect stimulatory effects on both cellular and humoral immunity. Likewise, an antitumor activity of melatonin has been shown in several experimental models in vivo and in vitro. The means by which melatonin exerts its effects on immunity and neoplastic growth have not been elucidated. The different putative mechanisms of action of melatonin investigated so far are here briefly discussed.

Citations

Feb 10, 2004·Journal of Occupational and Environmental Medicine·Travers Y IchinoseJohn S Reif
Apr 21, 2006·International Journal of Experimental Pathology·Sandra C MillerGeorges J M Maestroni
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Dec 14, 2011·Journal of Pineal Research·Virginia Alvarez-GarcíaSamuel Cos
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Jul 31, 2020·Biomedicines·Carolina Alonso-GonzálezSamuel Cos
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