Melatonin is a biomarker of circadian dysregulation and is correlated with major depression and fibromyalgia symptom severity

Journal of Pain Research
Wolnei CaumoLuciana C Antunes

Abstract

This study compared urinary 6-sulfatoxymelatonin (aMT6s) over 24 hours among fibromyalgia (FM), major depression disorder (MDD), and healthy control (HC) groups, and examined whether rhythm is correlated with depressive symptoms. To answer this question we compared the rhythm of urinary aMT6s secretion among each group in four time series: morning (06:00-12:00 hours), afternoon (12:00-18:00 hours), evening (18:00-24:00 hours), and night (24:00-06:00 hours). In the FM subjects, we assessed if the rhythm of urinary aMT6s secretion is associated with pain severity, sleep quality, number of trigger points (NTPs), and the pain pressure threshold (PPT). We included 54 women, aged 18-60 years with diagnosis of FM (n=18), MDD (n=19), and HC (n =17). The 24-hour urinary aMT6s was evaluated according to four standardized periods. The assessment instruments were the Hamilton Depression Rating Scale (HDRS), Pittsburgh Sleep Quality Index, and Fibromyalgia Impact Questionnaire. A generalized estimating equation revealed no difference in the daily load of aMT6s secretion among the three groups (P=0.49). However, at the daily time (06:00-18:00 hours), the load secretion of aMT6s reached 41.54% and 60.71% in the FM and MDD, respectively, as co...Continue Reading

Citations

Aug 28, 2019·Journal of Neural Transmission·Alberto Herrero BabiloniGilles J Lavigne
Jan 30, 2020·Cells·Alessandra StacchiottiLuigi Fabrizio Rodella
Dec 24, 2019·Frontiers in Neural Circuits·Chloé BouarabAbigail M Polter
Aug 17, 2019·Current Neuropharmacology·Darakhshan Jabeen Haleem
Jul 30, 2020·Medical Hypotheses·Boel De PaepeMira Meeus
Oct 21, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Rafael GenarioHeitor O Santos
Apr 14, 2020·Reumatología clinica·Diego Felipe García Rodríguez, Carlos Abud Mendoza
Mar 3, 2021·Pediatric Rheumatology Online Journal·Maya Levy ColesYosef Uziel
May 30, 2020·Progress in Neuro-psychopharmacology & Biological Psychiatry·G Anderson, M Maes

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Methods Mentioned

BETA
urine collection
ELISA

Software Mentioned

SPSS

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