Melatonin is protective against 6-hydroxydopamine-induced oxidative stress in a hemiparkinsonian rat model

Free Radical Research
Ozlem OzsoyMutay Aslan

Abstract

Melatonin is known to reduce detrimental effects of free radicals by stimulating antioxidant enzymes; however, its role has not been studied in 6-hydroxydopamine (6-OHDA)-induced rat model of Parkinson's disease (PD). Therefore, we aimed to elucidate the effects of melatonin on motor activity and oxidative stress parameters in 6-OHDA-induced rat model of PD. Three-month-old male Wistar rats were divided into 5 groups: vehicle (V), melatonin-treated (M), 6-OHDA-injected (6-OHDA), 6-OHDA-injected + melatonin-treated (6-OHDA-Mel), and melatonin-treated + 6-OHDA-injected (Mel-6-OHDA) group. Melatonin was administered intraperitoneally at a dose of 10 mg/kg/day for 30 days in M and Mel-6-OHDA groups, for 7 days in 6-OHDA-Mel group. Rats received a unilateral stereotaxic injection of 6-OHDA into the right medial forebrain bundle. The 6-OHDA-Mel group started receiving melatonin when experimental PD was created and the treatment was continued for 7 days. In the Mel-6-OHDA group, experimental PD was created on the 23rd day of melatonin treatment and continued for the remaining 7 days. Locomotor activity decreased in 6-OHDA group compared with that in vehicle group; however, melatonin treatment did not improve this impairment. 6-OHDA in...Continue Reading

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Citations

Nov 11, 2016·Oxidative Medicine and Cellular Longevity·Josiel Mileno MackRui Daniel Prediger
Aug 8, 2019·Cellular and Molecular Neurobiology·Omid Reza TamtajiZatollah Asemi
Aug 6, 2019·Frontiers in Endocrinology·Daniel P Cardinali
Oct 27, 2020·Oxidative Medicine and Cellular Longevity·Sandro PercárioMaria Fani Dolabela
Feb 5, 2021·Frontiers in Neuroscience·Andreza Fabro de BemJade de Oliveira
Mar 6, 2021·Metabolic Brain Disease·Özge GüzeladMutay Aslan
May 4, 2021·Frontiers in Pharmacology·Santiago Pérez-Lloret, Daniel P Cardinali

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