Abstract
The secretion of melatonin has been shown as abnormal in some depressed patients, but most such studies were conducted in the northern hemisphere and with severely depressed inpatients. The aim of this study was to evaluate melatonin excretion profiles in major depressive outpatients from São Paulo, Brazil, individually matched to well-screened healthy volunteers to examine whether melatonin abnormalities are also present in patients from the southern hemisphere, and in less severely ill patients. We analyzed 32 drug-free, depressed outpatients and 32 psychiatrically healthy volunteers matched for age and gender. We also examined a set of 15 drug-free depressed outpatients and 15 healthy volunteers that were matched not only for age and gender, but also for body mass index and season, all factors known to influence melatonin excretion in humans. All patients fulfilled DSM-IV criteria for major depression. We evaluated major urinary metabolite of melatonin, 6-sulphatoxymelatonin (aMT6s), produced over 24 h and divided into four periods (06:00-12:00, 12:00-08:00, 18:00-24:00 and 24:00-06:00 h). aMT6s measurements during the 24 and 6 h intervals were similar in the 32 depressed patients and 32 healthy volunteers matched for age an...Continue Reading
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