PMID: 2109291Mar 2, 1990Paper

Melatonin modulates diacylglycerol and arachidonic acid metabolism in the anterior pituitary of immature rats

Neuroscience Letters
J Vanĕcek, L Vollrath

Abstract

In pituitary glands of immature rats prelabeled in vitro with [3H]arachidonic acid, melatonin diminished the luteinizing hormone-releasing hormone (LHRH)-induced increase in [3H]diacylglycerol accumulation as well as [3H]arachidonic acid release from the tissue. Melatonin reduced also LHRH-stimulated incorporation of [3H]glycerol into pituitary [3H]diacylglycerol. The effect was day-time dependent: in the evening experiment melatonin was effective at 0.1 nM concentration while in the morning it had no effect even at 10 nM concentration. The effect of melatonin was also abolished by pretreatment with pertussis toxin. Diacylglycerol and/or arachidonic acid might serve as 2nd messengers transducing the effect of melatonin at the cellular level.

References

Jan 1, 1979·Neuroendocrinology·D E Blask, J L Nodelman
Dec 25, 1989·Brain Research·J Vanĕcek, L Vollrath
Dec 1, 1987·Brain Research·J VanĕcekH Illnerová
Aug 1, 1988·Neuroendocrinology·J Vanĕcek
Nov 1, 1988·Journal of Neurochemistry·J Vanĕcek
Jan 1, 1987·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·B H WhiteM D Rollag

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Citations

Feb 1, 1994·Neurochemistry International·P J MorganR Helliwell
Feb 1, 1994·Molecular and Cellular Endocrinology·S McNultyM H Hastings
Aug 27, 1999·Progress in Neurobiology·S B Udin, S Grant
Oct 1, 1994·Journal of Neuroendocrinology·S McNultyP J Morgan
Feb 1, 1995·British Journal of Pharmacology·D SugdenD F Lewis
Aug 11, 2010·Biochemical Pharmacology·Flavia RadognaLina Ghibelli
May 22, 2008·British Journal of Pharmacology·R JockersP Delagrange
Aug 17, 2001·Journal of Biological Rhythms·D G HazleriggS Messager
Jan 23, 2002·Molecular Reproduction and Development·Hang ZhaoAngela M S Poon
Oct 27, 1998·Chronobiology International·V M Cassone
Apr 3, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Oxana R KunduzovaAngelo Parini
Jul 23, 1998·Physiological Reviews·J Vanecek

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