PMID: 2510097Oct 9, 1989Paper

Melatonin modulates the sensitivity of 5-hydroxytryptamine-2 receptor-mediated sleep-wakefulness regulation in the rat

Neuroscience Letters
C DugovicA Wauquier

Abstract

The interaction between melatonin and two 5-hydroxytryptamine (5-HT2) compounds was studied on sleep patterns in rats. Administration of the 5-HT2 receptor antagonist ritanserin (0.63 mg/kg, i.p.) resulted in a significant increase of deep slow wave sleep (SWS2) and a decrease of paradoxical sleep (PS). The 5-HT2 receptor agonist DOM (1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane) (0.63 mg/kg, i.p.) produced a significant reduction of both SWS2 and PS. Melatonin (1 mg/kg, i.p.) alone did not alter sleep but counteracted the sleep effects induced by ritanserin as well as DOM. It is proposed that melatonin modulates the sensitivity of 5-HT2 receptor-mediated sleep response probably by an indirect route.

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Jan 1, 1988·Journal of Neural Transmission·N Zisapel
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Citations

Jul 20, 1993·European Journal of Pharmacology·G HuetherE Rüther
Jan 1, 1991·Schizophrenia Research·R Sandyk, S R Kay
Mar 14, 2000·Physiology & Behavior·L A Brotto, B B Gorzalka
Feb 28, 2001·Neuroscience Letters·F DragoF Foti
Apr 16, 2016·Expert Opinion on Therapeutic Targets·Paul Pévet
May 1, 1992·The International Journal of Neuroscience·R SandykM A Gillman
Mar 1, 1992·The International Journal of Neuroscience·R Sandyk
Apr 1, 1992·The International Journal of Neuroscience·R Sandyk
Jan 1, 1991·The International Journal of Neuroscience·R Sandyk, S R Kay
Mar 1, 1995·The International Journal of Neuroscience·R Sandyk
Jun 1, 1994·The International Journal of Neuroscience·R Sandyk, G I Awerbuch
Mar 1, 1995·The International Journal of Neuroscience·R Sandyk

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