Melatonin: Pharmacology, Functions and Therapeutic Benefits

Current Neuropharmacology
Sylvie TordjmanClaire Fougerou

Abstract

Melatonin synchronizes central but also peripheral oscillators (fetal adrenal gland, pancreas, liver, kidney, heart, lung, fat, gut, etc.), allowing temporal organization of biological functions through circadian rhythms (24-hour cycles) in relation to periodic environmental changes and therefore adaptation of the individual to his/her internal and external environment. Measures of melatonin are considered the best peripheral indices of human circadian timing based on an internal 24-hour clock. First, the pharmacology of melatonin (biosynthesis and circadian rhythms, pharmacokinetics and mechanisms of action) is described, allowing a better understanding of the short and long term effects of melatonin following its immediate or prolonged release. Then, research related to the physiological effects of melatonin is reviewed. The physiological effects of melatonin are various and include detoxification of free radicals and antioxidant actions, bone formation and protection, reproduction, and cardiovascular, immune or body mass regulation. Also, protective and therapeutic effects of melatonin are reported, especially with regard to brain or gastrointestinal protection, psychiatric disorders, cardiovascular diseases and oncostatic e...Continue Reading

Citations

May 17, 2018·Journal of Pineal Research·Zhijing ZhangChristophe P Ribelayga
Aug 1, 2018·International Journal of Molecular Sciences·Stephen C Bondy, Arezoo Campbell
Sep 22, 2018·Journal of Cellular Physiology·Bagher FarhoodAmirhossein Sahebkar
Dec 27, 2018·Journal of Pineal Research·María Elisa MercauCora Beatriz Cymeryng
Aug 4, 2018·Current Molecular Pharmacology·Peyman AminiMasoud Najafi
Mar 30, 2017·Pharmacological Reviews·Annabelle BallestaFrancis A Lévi
Oct 28, 2019·Expert Review of Gastroenterology & Hepatology·Yu JiYuchuan Ding
Dec 18, 2019·International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition·Paulina IwanMalgorzata Karbownik-Lewinska
Jan 23, 2020·Journal of Biochemical and Molecular Toxicology·Meryem SayanSaim Özdamar
Dec 24, 2019·Free Radical Research·Gagan B N Chainy, Dipak Kumar Sahoo
Apr 18, 2020·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Ryan T OglesbyGreg J Stanisz
Jun 23, 2020·Free Radical Research·Aiswarya PurushothamanDeepa Janardanan
May 19, 2020·Journal of Pineal Research·Hyocheol BaeWhasun Lim
Jun 11, 2020·Archives of Physiology and Biochemistry·Saptadip Samanta
Oct 3, 2018·American Journal of Therapeutics·Ahmed NaguyTarek Shoukry
Sep 21, 2020·Reviews in the Neurosciences·Sumaira KhanDivya Vohora
Oct 2, 2020·International Journal of Molecular Sciences·Fang LuoXin Wang
Sep 12, 2020·Pain Practice : the Official Journal of World Institute of Pain·Zhaoqi WangJun Ma
Aug 14, 2018·Pharmacological Reports : PR·Dasiel O Borroto-EscuelaKjell Fuxe
Jun 6, 2020·Antioxidants·Gabriella D'AngeloEloisa Gitto
Apr 17, 2020·Animals : an Open Access Journal From MDPI·Magdalena Prusik, Bogdan Lewczuk
Aug 19, 2020·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Natalia Llarena, Christopher Hine
Aug 18, 2020·Expert Opinion on Emerging Drugs·Sujit DebnathAbdelwahab Omri
Apr 7, 2018·Neural Regeneration Research·Reggie H C LeeHung Wen Lin
Dec 24, 2018·The Biochemical Journal·Antonio Villalobo
Jan 2, 2020·Pharmacology Research & Perspectives·Jean A Boutin, Céline Legros
Feb 12, 2020·International Journal of Environmental Research and Public Health·Julia Guerrero-GironésAntonio José Ortiz-Ruiz
Aug 28, 2020·Nutrients·Konrad KleszczyńskiRussel J Reiter
Dec 26, 2018·Journal of Clinical Medicine·Hiroki NishikawaShuhei Nishiguchi
May 19, 2020·Chronobiology International·Natalia Kurhaluk, Halyna Tkachenko

❮ Previous
Next ❯

Related Concepts

Related Feeds

Biomarkers for Cardiovascular Risk Assessment

Sensitive and accurate biomarkers used in cardiovascular risk prediction can potentially be used to manage the risk of cardiovascular disease. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here.

Related Papers

The Journal of Obstetrics and Gynaecology Research
Hiroshi TamuraNorihiro Sugino
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery
Venkataramanujam SrinivasanHisanori Kato
© 2022 Meta ULC. All rights reserved