Melatonin potentiates the effects of metformin on glucose metabolism and food intake in high-fat-fed rats

Endocrinology, Diabetes & Metabolism
Rosana F Dantas-FerreiraEtienne Challet

Abstract

Melatonin is a hormone synthesized mainly by the pineal gland, and secreted only at night. Melatonin has been proposed as a modulator of glucose metabolism. Here we studied the metabolic effects of melatonin administration alone (s.c. 10 mg/kg) or in combination with metformin (p.o. 300 mg/kg), a widely used anti-diabetic drug. These treatments were tested on glucose tolerance, insulin sensitivity and food intake in Zucker fatty rats (i.e., bearing a missense mutation in the leptin receptor gene) and high-fat fed Sprague-Dawley rats. Melatonin alone or in combination did not significantly modify glucose tolerance in either model. Melatonin alone in high-fat fed Sprague-Dawley improved insulin sensitivity to the level of metformin. In addition, combined treatment further ameliorated insulin sensitivity (+13%), especially during the late phase of rising glycemia. The lack of similar effects in Zucker rats suggests an involvement of leptin signaling in mediating the positive effects of melatonin. Body mass gain in Sprague-Dawley rats was decreased by both metformin, and combined metformin and melatonin. While melatonin alone did not markedly affect food intake, its combination with metformin led to a more pronounced anorexia (-17%...Continue Reading

References

Jan 24, 1995·European Journal of Pharmacology·J RouruM Jhanwar-Uniyal
Aug 7, 1998·European Journal of Clinical Investigation·G PaolissoF D'Onofrio
May 3, 2002·Clinical and Experimental Pharmacology & Physiology·Masami SuzukiHitoshi Ikeda
Sep 11, 2002·Journal of Pineal Research·Maria Cecília PicinatoAngelo Rafael Carpinelli
Aug 5, 2003·Endocrine·Stephaney S PuchalskiDennis D Rasmussen
Sep 13, 2003·Endocrinology·Bénédicte Prunet-MarcassusLuc Pénicaud
Aug 31, 2007·Proceedings of the National Academy of Sciences of the United States of America·Peng Y WoonDominique Gauguier
Feb 20, 2010·Obesity·Susana Contreras-AlcantaraGianluca Tosini
Mar 23, 2010·Metabolism: Clinical and Experimental·Grégory AubertFrançois P Pralong
Sep 15, 2011·Journal of Physiology, Paris·Paul Pevet, Etienne Challet
Jan 4, 2012·Annals of the New York Academy of Sciences·Julien Delezie, Etienne Challet
Sep 6, 2012·Diabetes & Metabolism Journal·Chang Koo LeeYong Woon Kim
Sep 13, 2012·Biochimica Et Biophysica Acta·Maayan BarneaOren Froy
Apr 4, 2013·JAMA : the Journal of the American Medical Association·Ciaran J McMullanJohn P Forman
Apr 10, 2013·Journal of Pineal Research·Ricardo ZanutoCarla R O Carvalho
May 7, 2013·Physiology & Behavior·M P TerrónA B Rodríguez
Mar 25, 2014·Journal of Pineal Research·J Cipolla-NetoR J Reiter
Aug 13, 2014·Journal of Pineal Research·Pilar Cano BarquillaDaniel P Cardinali
Apr 16, 2016·Trends in Endocrinology and Metabolism : TEM·Jingyi Qian, Frank A J L Scheer
May 12, 2016·Hormones and Behavior·Pavel HoudekAlena Sumová
May 18, 2016·Cell Metabolism·Tiinamaija TuomiHindrik Mulder
Dec 17, 2016·Diabetologia·Andrew C ForrestelMichael T Sellix
Feb 16, 2017·Journal of Pineal Research·Pengfei XuYonggong Zhai
Aug 5, 2017·Diabetologia·Graham RenaEwan R Pearson

❮ Previous
Next ❯

Citations

Oct 21, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Rafael GenarioHeitor O Santos
Nov 15, 2019·Neurochemistry International·Utcharaporn KamsrijaiPiyarat Govitrapong
May 18, 2021·Computational and Structural Biotechnology Journal·Kazuhiro TanabeKo Igami

❮ Previous
Next ❯

Methods Mentioned

BETA
ELISA

Software Mentioned

SigmaPlot
SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.