PMID: 11330842May 2, 2001Paper

Melatonin prevents delta-aminolevulinic acid-induced oxidative DNA damage in the presence of Fe2+

Molecular and Cellular Biochemistry
W QiJ R Calvo

Abstract

Delta-aminolevulinic acid (ALA), a heme precursor which accumulates during lead poisoning and acute intermittent porphyria, is reported to cause liver cancer. The carcinogenic mechanisms of ALA may relate to its ability to generate free radicals through metal-catalyzed oxidation which cause oxidative DNA damage. The aim of this study was to compare the efficacy of melatonin, trolox (vitamin E) and mannitol in altering DNA damage induced by ALA. Herein, we found, in the presence of Fe2+, that ALA-induced formation of 8-hydroxydeoxyguanosine in calf thymus DNA was dose and time-dependent. Melatonin, mannitol and trolox, all of which are free radical scavengers, inhibited the formation of 8-hydroxydeoxyguanosine in a concentration-dependent manner. The concentration of each (melatonin, mannitol and trolox) required to reduce DNA damage by 50%, i.e., the IC50, was 0.52, 0.84 and 0.90 mM, respectively.

Citations

Jul 29, 2009·Critical Reviews in Biochemistry and Molecular Biology·Russel J ReiterDan-Xian Tan
Apr 23, 2013·European Journal of Clinical Investigation·Miguel D FerrerAntoni Pons
Mar 3, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Annia GalanoRussel J Reiter
Nov 13, 2018·Journal of Pineal Research·Adriana Pérez-GonzálezAnnia Galano
Jul 1, 2005·Toxicology and Industrial Health·Fehmi OzgunerGokhan Cesur
Mar 19, 2014·Journal of Pineal Research·Alejandro RomeroRussel J Reiter
Jan 8, 2015·International Journal of Radiation Biology·Sarika SinghNeeru Kapoor
Apr 25, 2012·Emerging Health Threats Journal·Jeff DycheCecil Thomas
May 26, 2004·Journal of Inherited Metabolic Disease·E RocchiM D Cappellini
Nov 7, 2003·Bioelectromagnetics·József BakosGyörgy Thuróczy

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