PMID: 11316325Apr 24, 2001Paper

Melatonin prevents endotoxin-induced circulatory failure in rats

Journal of Pineal Research
C C WuM H Yen

Abstract

The pineal secretory product melatonin was found to exert protective effects in septic shock. In a host infected by bacterial lipopolysaccharide (LPS), the expression and release of proinflammatory tumor necrosis factor-alpha (TNF-alpha) is rapidly increased, suggesting that TNF-alpha is associated with the etiology of endotoxic shock. Recent reports show that the expression of NO synthase (NOS) II and the production of superoxide anion (O2*-) also contribute to the pathophysiology of septic shock. In the present study we demonstrate that melatonin prevents circulatory failure in rats with endotoxemia and improves survival in mice treated with a lethal dose of LPS. The beneficial hemodynamic effects of melatonin in the endotoxemic animal appear to be associated with the inhibition of (i) the release of TNF-alpha in plasma, (ii) the expression of NOS II in liver, and (iii) the production of O2*- in aortae. In addition, the infiltration of polymorphonuclear neutrophils into the liver from the surviving LPS mice treated with melatonin was reduced. Thus, our results support the clinical use of melatonin in endotoxemia.

Citations

May 29, 2007·Advances in Therapy·Tevfik YavuzOzlem Yavuz
Jul 5, 2007·Intensive Care Medicine·Boris PerrasChristoph Dodt
Jan 18, 2005·Naunyn-Schmiedeberg's Archives of Pharmacology·Chin-Wei ChiaoMing-Jai Su
May 27, 2005·Journal of Biomedical Science·Shinn-Long LinMao-Hsiung Yen
Nov 9, 2006·Journal of Biomedical Science·Shyi-Shiaw JiauMao-Hsiung Yen
May 16, 2002·Neurobiology of Aging·Yuji OkataniYasuyo Miyahara
Sep 27, 2002·Toxicology·Susana Cadenas, Ana M Cadenas
Jan 30, 2010·Zygote : the Biology of Gametes and Early Embryos·Gaia IzzoMichela d'Istria
Apr 5, 2011·Critical Care : the Official Journal of the Critical Care Forum·Ricardo CastroMatt R Rosengart
Feb 2, 2008·World Journal of Gastroenterology : WJG·Alper AkcanYucel Aritas
Dec 25, 2010·World Journal of Gastroenterology : WJG·Alexander M Mathes
Feb 18, 2014·CNS Drugs·Rodrigo Fernández-GajardoRamón Rodrigo
May 23, 2013·Age·Arezoo CampbellStephen C Bondy
Jan 5, 2014·Inflammation·Katharina Effenberger-NeidnichtHerbert de Groot
Oct 22, 2013·Journal of Critical Care·Mahdi AlamiliIsmail Gögenur
May 4, 2010·Journal of Critical Care·Venkataramanujan SrinivasanDaniel P Cardinali
Jan 19, 2010·Journal of Photochemistry and Photobiology. B, Biology·C Haldar, R Ahmad
May 12, 2009·The Veterinary Journal·Barbara A Murphy
Oct 23, 2013·Critical Care Medicine·Tobias FinkAlexander M Mathes
May 8, 2007·Nutrition·Guhapriya MoorthyS Niranjali Devaraj
Dec 22, 2006·Biochemical Pharmacology·Pao-Yun ChengMao-Hsiung Yen
Oct 20, 2006·Experimental Gerontology·Germaine EscamesDarío Acuña-Castroviejo
Sep 2, 2006·The Journal of Pharmacy and Pharmacology·Germaine EscamesRussel J Reiter
Mar 21, 2007·The FEBS Journal·Germaine EscamesDarío Acuña-Castroviejo
Sep 7, 2007·Journal of Pineal Research·Caterina PeñaJesus Mosquera
Mar 12, 2011·Journal of Pineal Research·Xiao-Jing LinMao-Tsun Lin
Mar 2, 2011·Journal of Pineal Research·Hua WangDe-Xiang Xu
Nov 1, 2011·American Journal of Reproductive Immunology : AJRI·Masoud HemadiAli Khodadai

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.