Melatonin prevents oxidative damage induced by maternal ethanol administration and reduces homocysteine in the cerebellum of rat pups

Behavioural Brain Research
Farzaneh BagheriMahmoud Elahdadi Salmani

Abstract

Chronic alcoholism leads to elevated plasma and brain homocysteine (Hcy) levels, as demonstrated by animal experiments. This study was designed to evaluate the alterations in offspring rat cerebellum following increase of plasma Hcy level induced by maternal exposure to ethanol and to investigate the possible protective role of melatonin administration upon cerebellar ethanol-induced neurotoxicity. The adult female rats were divided randomly into 4 groups, including one control and three experimental groups, after vaginal plagues. Group I received normal saline, group II received ethanol (4 g/kg), group III received ethanol+melatonin (10mg/kg) and group IV received melatonin on day 6 of gestation until weaning. 21 days after birth, plasma Hcy level, level of lipid peroxidation, the activities of several antioxidant enzymes including superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and levels of bcl-2 and bax mRNA expression in cerebellum were determined. Our results demonstrated that ethanol could induce lipid peroxidation, and decrease antioxidants activities and increase plasma total Hcy level. We also observed that ethanol impaired performance on the rotarod and locomotor activities of rats. However,...Continue Reading

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Citations

Jul 22, 2015·Physiology & Behavior·Maryam BazrgarMahmoud Elahdadi Salmani
Sep 12, 2018·Cell Biology International·Marcelo MartinezFrancisco E Martinez
Nov 3, 2016·Alcoholism, Clinical and Experimental Research·Pradip K KamatNeetu Tyagi
Oct 15, 2019·Nutritional Neuroscience·Rahebeh MahdiniaMahmoud Elahdadi Salmani
Aug 25, 2021·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Rahebeh MahdiniaMahmoud Elahdadi Salmani

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