Melatonin protects against delta-aminolevulinic acid-induced oxidative damage in male Syrian hamster Harderian glands

The International Journal of Biochemistry & Cell Biology
Cristina Tomás-ZapicoAna Coto-Montes

Abstract

Effects of the prooxidant delta-aminolevulinic acid (ALA) and the antioxidant melatonin (MEL) were investigated in the male Syrian hamster Harderian gland (HG). Rodent Harderian glands are highly porphyrogenic organs, which may be used as model systems for studying damage by delta-aminolevulinic acid and its metabolites, as occurring in porphyrias. Chronic administration of delta-aminolevulinic acid (2 weeks) markedly decreased activities of the porphyrogenic enzymes delta-aminolevulinate synthase (ALA-S) and delta-aminolevulinate dehydratase (ALA-D) and of the antioxidant enzymes superoxide dismutase (SOD), glutathione reductase (GR) and catalase (CAT), whereas porphobilinogen deaminase (PBG-D) remained unaffected. This treatment led to increased lipid peroxidation (LPO) and oxidatively modified protein (protein carbonyl) as well as to morphologically apparent tissue damage. Melatonin also caused decreases in delta-aminolevulinate synthase, delta-aminolevulinate dehydratase, superoxide dismutase, glutathione reductase and catalase. Despite lower activities of antioxidant enzymes, lipid peroxidation and protein carbonyl were markedly diminished. The combination of delta-aminolevulinic acid and melatonin led to approximately nor...Continue Reading

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Citations

Sep 24, 2005·Neurotoxicity Research·V SrinivasanD P Cardinali
May 12, 2009·BMC Cancer·Thissiane L GonçalvesJoão Batista T Rocha
Dec 7, 2013·Histochemistry and Cell Biology·M García-MaciaA Coto-Montes
Jun 28, 2005·Journal of Pineal Research·Cristina Tomás-ZapicoAna Coto-Montes
Jan 31, 2006·Journal of Pineal Research·Patricia J LardoneAna Coto-Montes
May 12, 2012·Molecular and Cellular Endocrinology·Ana Coto-MontesRussel J Reiter
Oct 20, 2011·Human Molecular Genetics·Silvia CorrochanoAbraham Acevedo-Arozena
Sep 6, 2018·Neural Computation·Beatrice Alexandra Golomb
Feb 6, 2008·Journal of Cellular Physiology·Alessandra SantilloGabriella Chieffi Baccari
Aug 16, 2005·Journal of Pineal Research·Cristina Tomás-Zapico, Ana Coto-Montes
Feb 16, 2006·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Beatriz CaballeroAna Coto-Montes
Sep 28, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Cristina Tomás-ZapicoAna Coto-Montes

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