Melatonin protects against endosulfan-induced oxidative tissue damage in rats

Journal of Pineal Research
Gülden Z OmurtagGöksel Sener

Abstract

Endosulfan is a chlorinated cyclodiene insecticide which induces oxidative stress. In this study, we investigated the possible protective effect of melatonin, an antioxidant agent, against endosulfan (Endo)-induced toxicity in rats. Wistar albino rats (n = 8) were administered endosulfan (22 mg/kg/day orally) followed by either saline (Endo group) or melatonin (10 mg/kg/day, Endo + Mel group) for 5 days. In other rats, saline (control group) or melatonin (10 mg/kg/day, Mel group) was injected for 5 days, following corn oil administration (vehicle of endosulfan). Measurement of malondialdehyde (MDA) and glutathione (GSH) levels, myeloperoxidase (MPO) activity and collagen content were performed in liver and kidney. Furthermore, aspartate aminotransferase (AST), alanine aminotransferase (ALT), blood urea nitrogen (BUN), and creatinine levels, lactate dehydrogenase (LDH) activity were measured in the serum samples, while tumor necrosis factor-alpha (TNF-alpha), interleukin-beta (IL-beta) and total antioxidant capacity (AOC) were assayed in plasma samples. Endosulfan administration caused a significant decrease in tissue GSH and plasma AOC, which was accompanied with significant rises in tissue MDA and collagen levels and MPO activ...Continue Reading

References

Jan 1, 1978·Methods in Enzymology·J A Buege, S D Aust
Dec 1, 1990·Journal of Pharmacological Methods·L M HillegassC Albrightson-Winslow
Aug 1, 1985·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·A López-De León, M Rojkind
Jan 1, 1987·Archives of Toxicology·H Kappus
Mar 1, 1987·Bulletin of Environmental Contamination and Toxicology·B D Banerjee, Q Z Hussain
Aug 1, 1972·Clinica Chimica Acta; International Journal of Clinical Chemistry·R G Martinek
Jan 1, 1965·Scandinavian Journal of Clinical and Laboratory Investigation·C Slot
Jan 1, 1995·Biological Trace Element Research·F HincalB Giray
Jan 1, 1994·Life Sciences·C PieriF Marcheselli
Jun 1, 1993·Comparative Biochemistry and Physiology. Comparative Physiology·F J Schweigert
Jan 1, 1997·Life Sciences·E GiladC Szabó
Jul 22, 1999·Toxicology Letters·B D BanerjeeA K Chakraborty
Feb 22, 2000·Journal of Bioenergetics and Biomembranes·J J GarcíaD Acuña-Castroviejo
May 31, 2001·Environmental Toxicology and Pharmacology·N SinhaD K Saxena
Jun 19, 2002·Bulletin of Environmental Contamination and Toxicology·N SethunathanR Naidu
Jul 5, 2003·Molecular and Cellular Biochemistry·Krishnaswamy Kannan, Sushil K Jain
Feb 1, 1965·Klinische Wochenschrift·H TALKE, G E SCHUBERT
Dec 17, 2003·Journal of Pineal Research·Carmen RodriguezRussel J Reiter
May 20, 2005·The Journal of Pharmacy and Pharmacology·Gülden Z OmurtagGöksel Sener
Jan 31, 2007·Biochemical and Biophysical Research Communications·Eun Hee HanHye Gwang Jeong
Feb 1, 1997·Redox Report : Communications in Free Radical Research·A J Kettle, C C Winterbourn

❮ Previous
Next ❯

Citations

Dec 25, 2010·World Journal of Gastroenterology : WJG·Alexander M Mathes
Apr 22, 2014·International Journal of Molecular Sciences·Sara SalucciElisabetta Falcieri
Jun 15, 2011·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·M Khaksary MahabadyE Bakhtiari
Jan 27, 2011·Biochemical and Biophysical Research Communications·Vinicius KannenSérgio B Garcia
Nov 17, 2009·Ecotoxicology and Environmental Safety·Gamal H El-SokkaryElhammaly H Shabash
Sep 3, 2009·Annals of the New York Academy of Sciences·Silvia CristofanonMarc Diederich
Jul 22, 2015·Physiology & Behavior·Maryam BazrgarMahmoud Elahdadi Salmani
Jul 28, 2011·Fundamental & Clinical Pharmacology·Amit K SharmaSwapan K Bhattacharya
Apr 16, 2014·Environmental Toxicology·Kapil D MehtaKrishna K Sharma
Sep 10, 2014·Archives of Toxicology·Hyung Gyun KimHye Gwang Jeong
Apr 20, 2016·Arhiv za higijenu rada i toksikologiju·Tae-chang JangKyung-won Lee
Sep 18, 2013·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Gurpreet SinghG S S Saini
Jan 10, 2012·International Immunopharmacology·Chang LiuYongqiu Zheng
Jun 7, 2016·Pesticide Biochemistry and Physiology·Arif Ahmad PanditR S Sethi
Jul 20, 2016·Expert Opinion on Drug Metabolism & Toxicology·Mohammad Hossein AsghariMohammad Abdollahi
Feb 12, 2008·Ecotoxicology and Environmental Safety·Ozer SehirliGöksel Sener
Dec 3, 2016·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Belén Gómez-GiménezVicente Felipo
Apr 14, 2010·Human & Experimental Toxicology·Rahul PathakB D Banerjee
May 6, 2011·Toxicology and Industrial Health·Friday Effiong UbohMbeh Ubana Eteng
Sep 6, 2018·Neural Computation·Beatrice Alexandra Golomb
Sep 29, 2011·Molecular Biology Reports·A Ata AlturfanGülden Zehra Omurtag
Jun 15, 2019·Acta Neuropathologica·Jason R RichardsonAnumantha G Kanthasamy
Jun 14, 2019·Dose-response : a Publication of International Hormesis Society·Manar A AlwelaieHaseeb A Khan
Oct 1, 2020·Environmental Science and Pollution Research International·Supriya SharmaFaheem Hyder Pottoo

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.