PMID: 11316326Apr 24, 2001Paper

Melatonin protects against streptozotocin, but not interleukin-1beta-induced damage of rodent pancreatic beta-cells

Journal of Pineal Research
A K Andersson, S Sandler

Abstract

In the present study, we examined whether melatonin can protect rodent pancreatic islets against streptozotocin (STZ) and interleukin-1beta (IL-1beta)-induced suppression of beta-cell function. Formation of free radicals, DNA damage and extensive DNA repair leading to depletion of intracellular nicotinamide adenine dinucleotide (NAD) may mediate STZ toxicity. Activation of inducible nitric oxide synthase and nitric oxide (NO) formation may cause IL-1beta -induced beta-cell impairment. We also studied the effect of melatonin against STZ-induced hyperglycemia in C57BL/Ks mice. For in vitro studies, cultured rat islets were exposed to melatonin (100 microM-1 mM) 30 min prior to STZ (0.5 mM) or IL-1beta (25 U/mL) addition. After an additional 30 min incubation with STZ, islet function and NAD content were analyzed either acutely or after 18 hr of recovery in fresh culture medium. For IL-1beta experiments, islets were incubated for 48 hr with the cytokine before evaluation of islet function. We found that melatonin counteracted STZ-induced inhibition of glucose metabolism and insulin release in cultured rat islets after 18 hr of recovery. Moreover, NAD levels were higher in the melatonin-treated group at this time point. Melatonin h...Continue Reading

Citations

Apr 15, 2004·Life Sciences·Carlos F Reyes-TosoDaniel P Cardinali
May 3, 2007·Biological & Pharmaceutical Bulletin·Kyoung Ah KangJin Won Hyun
Dec 6, 2002·Drugs·Nikolai PetrovskyDesmond A Schatz
Aug 24, 2011·World Journal of Diabetes·Javier EspinoAna B Rodríguez
Aug 3, 2002·Journal of Pineal Research·Carlos F Reyes-TosoDaniel P Cardinali
Oct 30, 2007·Life Sciences·Carlos F Reyes-TosoDaniel P Cardinali
Mar 11, 2004·Journal of Pineal Research·Jolanta JaworekWiesław W Pawlik
Jul 16, 2008·Journal of Pineal Research·Elmar PeschkeEckhard Muhlbauer
Feb 28, 2006·Journal of Pineal Research·Francisco C Muñoz-CasaresJordi Muntané
Dec 15, 2007·Journal of Pineal Research·Elmar Peschke
Apr 29, 2015·Journal of Molecular Endocrinology·Joong Kwan KimHyeon Soo Kim
Nov 15, 2011·Molecular and Cellular Endocrinology·Ahmet KorkmazRussel J Reiter
Aug 12, 2018·Diabetes/metabolism Research and Reviews·Begum Gurel-GokmenTugba Tunali-Akbay
Dec 24, 2019·Free Radical Research·Gagan B N Chainy, Dipak Kumar Sahoo
Sep 29, 2004·Journal of Enzyme Inhibition and Medicinal Chemistry·Sükrü Beydemir, Ilhami Gülçin
Sep 11, 2002·Journal of Pineal Research·Ilhami GulcinO Irfan Kufrevioglu
Mar 29, 2003·Journal of Pineal Research·Ilhami GulcinO Irfan Kufrevioglu
May 29, 2021·Archives of Physiology and Biochemistry·Chang GuoGuoyue Yuan

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