Melatonin protects the retina from experimental nonexudative age-related macular degeneration in mice.

Journal of Pineal Research
Hernán H DieguezDamián Dorfman

Abstract

Nonexudative age-related macular degeneration (NE-AMD) represents the leading cause of blindness in the elderly. Currently, there are no available treatments for NE-AMD. We have developed a NE-AMD model induced by superior cervical ganglionectomy (SCGx) in C57BL/6J mice, which reproduces the disease hallmarks. Several lines of evidence strongly support the involvement of oxidative stress in NE-AMD-induced retinal pigment epithelium (RPE) and outer retina damage. Melatonin is a proven and safe antioxidant. Our aim was analysing the effect of melatonin in the RPE/outer retina damage within experimental NE-AMD. The treatment with melatonin starting 48 h after SCGx, which had no effect on the ubiquitous choriocapillaris widening, protected visual functions and avoided Bruch´s membrane thickening, RPE melanin content, melanosome number loss, retinoid isomerohydrolase (RPE65)-immunoreactivity decrease, and RPE and hotoreceptor ultrastructural damage induced within experimental NE-AMD exclusively located at the central temporal (but not nasal) region. Melatonin also prevented the increase in outer retina/RPE oxidative stress markers and a decrease in mitochondrial mass at 6 weeks post-SCGx. Moreover, when the treatment with melatonin ...Continue Reading

References

Feb 16, 2000·Progress in Retinal and Eye Research·J CaiD P Jones
Jul 20, 2002·Experimental Eye Research·Jena J SteinlePeter G Smith
Jan 23, 2003·International Journal of Toxicology·Pierrette Dayhaw-Barker
Dec 17, 2003·Journal of Pineal Research·Carmen RodriguezRussel J Reiter
Jan 7, 2004·Journal of Photochemistry and Photobiology. B, Biology·Mario CiuffiPaola Failli
Apr 14, 2004·Archives of Ophthalmology·Marco A Zarbin
Apr 28, 2004·Experimental Eye Research·Fong-Qi LiangBernard F Godley
Mar 11, 2005·Expert Opinion on Emerging Drugs·Grant M ComerMark H Criswell
Jun 28, 2005·Neurobiology of Aging·Janos FeherCorrado Balacco Gabrieli
Jan 10, 2006·Annals of the New York Academy of Sciences·Changxian YiWalter Pierpaoli
Jan 31, 2006·Journal of Pineal Research·Andrew W SiuRussel J Reiter
Nov 15, 2008·The American Journal of Pathology·Pablo Horacio SandeRuth Estela Rosenstein
Nov 26, 2008·Progress in Retinal and Eye Research·Xiaoyan DingChi-Chao Chan
Jul 29, 2009·Critical Reviews in Biochemistry and Molecular Biology·Russel J ReiterDan-Xian Tan
Sep 15, 2009·Progress in Retinal and Eye Research·J C BooijA A B Bergen
Apr 9, 2010·Journal of Pineal Research·Nicolás A BelforteRuth E Rosenstein
May 19, 2010·Progress in Brain Research·Russel J ReiterLorena Fuentes-Broto
May 28, 2010·Investigative Ophthalmology & Visual Science·Pabalu P KarunadharmaDeborah A Ferrington
Jul 19, 2011·Journal of Pineal Research·María José Del SoleRuth E Rosenstein
Dec 29, 2011·Frontiers in Bioscience (Landmark Edition)·Yang FuXun Xu
Jun 26, 2012·Journal of Pineal Research·José L MaurizJavier González-Gallego
Sep 25, 2012·Journal of Pineal Research·Annia GalanoRussel J Reiter
Dec 4, 2012·International Journal of Molecular Sciences·Janusz BlasiakKai Kaarniranta
Feb 26, 2013·International Journal of Molecular Sciences·Janusz BlasiakKai Kaarniranta
Oct 10, 2013·The Journal of Pathology·Menno van Lookeren CampagneWeilan Ye
Oct 15, 2013·Current Biology : CB·Melis Yilmaz, Markus Meister
Nov 13, 2013·Experimental Eye Research·Mira M SachdevaJames T Handa
Dec 18, 2013·Investigative Ophthalmology & Visual Science·Catherine Bowes RickmanMikael Klingeborn
Jul 6, 2014·Investigative Ophthalmology & Visual Science·Haoyu MaoAlfred S Lewin
Jul 26, 2014·Journal of Pineal Research·Hong-Mei Zhang, Yiqiang Zhang
Aug 12, 2014·CNS & Neurological Disorders Drug Targets·Begoña M EscribanoIsaac Túnez
Aug 19, 2014·British Journal of Pharmacology·P H SandeD A Sáenz
May 12, 2015·Veterinary Ophthalmology·Pablo H SandeRuth E Rosenstein
Jul 18, 2015·Journal of Clinical Pharmacology·Lars P H AndersenIsmail Gögenur
Aug 15, 2015·Journal of Pineal Research·Lucien C ManchesterRussel J Reiter
Oct 3, 2015·Advances in Experimental Medicine and Biology·Mandy L Lambros, Scott M Plafker
Oct 27, 2015·Developments in Ophthalmology·Stephan Michels, Gerhard Garhöfer
Feb 18, 2016·Journal of Pineal Research·Marcos L ArandaRuth E Rosenstein
May 10, 2016·Progress in Retinal and Eye Research·Nathan G LambertBalamurali K Ambati
Jul 12, 2016·Nature Neuroscience·Jung-Hwan A LimAndrew D Huberman

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Citations

Jan 1, 2021·Ophthalmology·Kenneth C FanAudina M Berrocal
Oct 20, 2020·Pharmacology & Therapeutics·Xiaoyu TianRutao Cui
Mar 7, 2021·Biomolecules·Alejandro Martínez-ÁguilaGonzalo Carracedo
Apr 1, 2021·Molecular Neurobiology·María F González FleitasRuth E Rosenstein

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