Melatonin receptor activation increases glutamatergic synaptic transmission in the rat medial lateral habenula

Synapse
Katherine M EvelySamir Haj-Dahmane

Abstract

Melatonin (MLT) is secreted from the pineal gland and mediates its physiological effects through activation of two G protein-coupled receptors, MT1 and MT2 . These receptors are expressed in several brain areas, including the habenular complex, a pair of nuclei that relay information from forebrain to midbrain and modulate a plethora of behaviors, including sleep, mood, and pain. However, so far, the precise mechanisms by which MLT control the function of habenula neurons remain unknown. Using whole cell recordings from male rat brain slices, we examined the effects of MLT on the excitability of medial lateral habenula (MLHb) neurons. We found that MLT had no significant effects on the intrinsic excitability of MLHb neurons, but profoundly increased the amplitude of glutamate-mediated evoked excitatory post-synaptic currents (EPSC). The increase in strength of glutamate synapses onto MLHb neurons was mediated by an increase in glutamate release. The MLT-induced increase in glutamatergic synaptic transmission was blocked by the competitive MT1 /MT2 receptor antagonist luzindole (LUZ). These results unravel a potential cellular mechanism by which MLT receptor activation enhances the excitability of MLHb neurons. The MLT-mediated ...Continue Reading

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Citations

Jun 18, 2016·British Journal of Pharmacology·Ralf JockersDarius P Zlotos
Apr 8, 2017·Nutrients·Xiao MengHua-Bin Li
Jun 26, 2017·Pharmacology, Biochemistry, and Behavior·Daniel S Zahm, David H Root
Mar 8, 2018·British Journal of Pharmacology·Marcela Valdés-TovarGloria Benítez-King
May 10, 2017·Brain Structure & Function·Khuen Yen NgGeorge Paxinos
Aug 8, 2018·International Journal of Molecular Sciences·Rosa Estrada-ReyesGloria Benítez-King
Feb 23, 2019·Frontiers in Psychiatry·Anna MaruaniRichard Delorme
May 2, 2018·Journal of Alzheimer's Disease : JAD·Yan ShiQing Tian
Mar 23, 2021·Frontiers in Molecular Neuroscience·Chengxi LiuMazhong Zhang
Apr 27, 2021·Frontiers in Psychiatry·André C TononElaine Elisabetsky

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