Melatonin receptor agonist protects against acute lung injury induced by ventilator through up-regulation of IL-10 production

Respiratory Research
Geng-Chin WuShi-Jye Chu

Abstract

It is well known that ventilation with high volume or pressure may damage healthy lungs or worsen injured lungs. Melatonin has been reported to be effective in animal models of acute lung injury. Melatonin exerts its beneficial effects by acting as a direct antioxidant and via melatonin receptor activation. However, it is not clear whether melatonin receptor agonist has a protective effect in ventilator-induced lung injury (VILI). Therefore, in this study, we determined whether ramelteon (a melatonin receptor agonist) can attenuate VILI and explore the possible mechanism for protection. VILI was induced by high tidal volume ventilation in a rat model. The rats were randomly allotted into the following groups: control, control+melatonin, control+ramelteon, control+luzindole, VILI, VILI+luzindole, VILI + melatonin, VILI + melatonin + luzindole (melatonin receptor antagonist), VILI + ramelteon, and VILI + ramelteon + luzindole (n = 6 per group). The role of interleukin-10 (IL-10) in the melatonin- or ramelteon-mediated protection against VILI was also investigated. Ramelteon treatment markedly reduced lung edema, serum malondialdehyde levels, the concentration of inflammatory cytokines in bronchoalveolar lavage fluid (BALF), NF-κB...Continue Reading

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Citations

Jun 25, 2020·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·William BushellPaul J Mills
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Oct 12, 2021·Drug and Chemical Toxicology·Meltem ÖzgöçmenAli Mustafaoğlu

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Methods Mentioned

BETA
bronchoalveolar lavage
ELISA
protein assay
MDA
nuclear translocation

Software Mentioned

GraphPad Prism

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