Melatonin receptors in benign prostate epithelial cells: evidence for the involvement of cholera and pertussis toxins-sensitive G proteins in their signal transduction pathways

The Prostate
E GiladN Zisapel

Abstract

Melatonin, the hormone secreted nocturnally by the pineal gland, binds to epithelial cells from the human benign prostate, and can reduce their growth and viability. The possible involvement of GTP binding proteins cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) in melatonin responses in these cells were investigated. The effects of melatonin on cAMP and cGMP were assessed in prostate cells untreated or pretreated with pertussis toxin (PTX) or cholera toxin (CTX). Melatonin augmented cAMP but reduced cGMP in the epithelial cells (maximal responses at 10 nM). The increase in cAMP was attenuated by PTX, but not by CTX, whereas the decrease in cGMP was attenuated by CTX, but not by PTX. CTX, but not PTX, abolished the melatonin-mediated suppression of 3H-thymidine incorporation. In addition, melatonin facilitated the CTX- and PTX-mediated ADP ribosylation of 44- and 41-kilodalton proteins, respectively. The cGMP analogue 8-bromo-cGMP, negated the melatonin-mediated decrease in 3H-thymidine incorporation, whereas H89, a protein kinase A inhibitor, did not inhibit melatonin's effect. Melatonin receptors in the human benign prostate epithelial cells enhance cAMP and inhibit cGMP through PTX- and CTX-se...Continue Reading

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Citations

Jul 17, 2009·Pharmacological Reports : PR·Jolanta B ZawilskaJosephine Arendt
Sep 19, 2012·Progress in Retinal and Eye Research·Hai HuangXiong-Li Yang
Mar 11, 2006·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·C Ekmekcioglu
Jan 23, 2002·Molecular Reproduction and Development·Hang ZhaoAngela M S Poon
Feb 18, 2011·European Journal of Nutrition·Pía VillarroelMiguel Arredondo
Jun 18, 2020·Cancers·Sangiliyandi GurunathanJin-Hoi Kim

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