PMID: 9541644Apr 29, 1998Paper

Melatonin reduces gamma radiation-induced primary DNA damage in human blood lymphocytes

Mutation Research
VijayalaxmiM L Meltz

Abstract

Peripheral blood samples were collected from human volunteers 5-10 min before, and at 1 and 2 h after a single oral dose of 300 mg of melatonin. At each time point: (1) the concentration of melatonin in the serum and in the leukocytes was determined; and (2) the whole blood was exposed in vitro to 100 cGy of gamma radiation. Immediately after exposure to the radiation, the lymphocytes were examined to determine the extent of primary DNA damage, viz., single strand breaks and alkali labile lesions (determined from the length of DNA migration and fluorescence intensity of migrated DNA in the comet tail), using the alkaline comet assay. For each volunteer, the results showed a significant increase in the concentration of melatonin in the serum and in the leukocytes at 1 h after the oral dose of melatonin, as compared to the sample collected at 0 hour. The lymphocytes in the blood samples collected at 1 and 2 h after melatonin ingestion and exposed in vitro to 100 cGy gamma radiation exhibited a significant decrease in the extent of primary DNA damage, as compared with similarly irradiated lymphocytes from the blood sample collected before melatonin ingestion. The extent of the melatonin-associated decrease in primary DNA damage di...Continue Reading

References

Mar 1, 1992·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·R J Reiter
Mar 1, 1988·Experimental Cell Research·N P SinghE L Schneider
May 1, 1995·Neurochemistry International·L R Barlow-WaldenB Poeggeler
Jul 1, 1993·Mutation Research·V J McKelvey-MartinA Collins
Feb 1, 1995·Mutation Research·D W FairbairnK L O'Neill
Jan 1, 1994·Life Sciences·C PieriF Marcheselli
May 1, 1995·Journal of Pineal Research·C Carlberg, I Wiesenberg
Jan 1, 1997·Life Sciences·E GiladC Szabó

❮ Previous
Next ❯

Citations

Nov 19, 2003·Life Sciences·Göksel SenerBerrak C Yeğen
Sep 5, 1998·Mutation Research· VijayalaxmiT S Herman
Mar 20, 1999·Mutation Research· VijayalaxmiK S Kumar
Jun 7, 2003·Critical Reviews in Oncology/hematology·Vladimir N Anisimov
Sep 21, 2000·Proceedings of the Society for Experimental Biology and Medicine·M Karbownik, R J Reiter
Jun 29, 2004·Anatomical Science International·Takashi KachiYoshikazu Tonosaki
Nov 29, 2014·TheScientificWorldJournal·Ehsan MihandoostAkbar Aliasgharzadeh
Apr 2, 2011·Journal of Pineal Research·Russel J ReiterLucien C Manchester
Sep 1, 2004·Current Therapeutic Research, Clinical and Experimental·Neşe Kiremit-KorkutHatice Bilge
Sep 1, 2004·Environmental Toxicology and Pharmacology·A L Bhatia, Kailash Manda
Jul 25, 2015·Journal of Biomedical Science·Shahanshah KhanNabo Kumar Chaudhury
May 9, 2006·Biochimica Et Biophysica Acta·Vladimir N AnisimovIrina A Vinogradova
May 16, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology· VijayalaxmiTerence S Herman
May 10, 2017·International Journal of Molecular Sciences·Ahmed Esmat Abdel MoneimGermaine Escames
Jun 9, 2004·International Journal of Radiation Oncology, Biology, Physics· VijayalaxmiCharles R Thomas
Oct 31, 2003·Toxicologic Pathology·Vladimir N Anisimov
Aug 4, 2018·Current Molecular Pharmacology·Peyman AminiMasoud Najafi
Jul 20, 2018·Journal of Microscopy and Ultrastructure·Elfide Gizem KıvrakGamze Altun
Aug 24, 2018·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·B FarhoodM Najafi
Jul 21, 2007·Journal of Radiation Research·Alireza ShiraziMahmoud Ghazi-Khansari
Jul 22, 2020·Reviews in Endocrine & Metabolic Disorders·Andreea Iulia SocaciuArmand Gabriel Râjnoveanu
Apr 18, 2018·Reproduction in Domestic Animals = Zuchthygiene·H S TalpurL Yang
Aug 23, 2020·International Journal of Molecular Sciences·Jarosław NuszkiewiczKarolina Szewczyk-Golec
Apr 20, 2004·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Ulko UndegerNurçen Baçaran

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.