PMID: 8989719Nov 1, 1996Paper

Melatonin reduces mortality from Aleutian disease in mink (Mustela vison)

Journal of Pineal Research
L C Ellis

Abstract

Aleutian disease (AD) results from a persistent parvoviral infection that results in marked hypergammaglobulinemia and immune complex mediated lesions of the kidney, liver, lungs and, arteries. Melatonin protected both a wild type or demi strain and a demi/dark crossed strain of mink from AD. The biogenic amine also afforded protection against other non-diagnosed diseases naturally found on mink farms when it was available from a subcutaneously-placed reservoir. Some genetic strains of mink apparently differed in the resistance of mink to the virus and in the protective ability of melatonin. The demi strain was the most resistant followed by pastels, mahogany, darks, and those strains with the double recessive Aleutian gene. The protective action of melatonin appeared to result from melatonin's ability to scavenge free radicals, but it could also be due to the induction of antioxidant enzymes or to the modulation of immunity. Melatonin also protected mink against distemper.

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Citations

Mar 4, 2008·Journal of the American Veterinary Medical Association·Matthew C AllenderDanielle Reel
Feb 27, 2009·Molecular Ecology·A G KiddA I Schulte-Hostedde
Apr 19, 2012·Reviews in Medical Virology·Jose Antonio BogaRussel J Reiter
Jun 3, 2016·Acta Veterinaria Scandinavica·Trine Hammer JensenMette Sif Hansen
Oct 27, 2015·Cell Transplantation·Nate WatsonCesar V Borlongan
Apr 24, 2013·International Journal of Molecular Sciences·Antonio Carrillo-VicoJuan M Guerrero
May 30, 2009·American Journal of Men's Health·John L OliffeLawrence Mroz
Jul 14, 2020·Fundamental & Clinical Pharmacology·Hakan ParlakpinarHaci Ahmet Acet
Apr 2, 1999·Antimicrobial Agents and Chemotherapy·I WiidP van Helden

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