Melatonin reduces prostate cancer cell growth leading to neuroendocrine differentiation via a receptor and PKA independent mechanism

The Prostate
Rosa M SáinzR J Reiter

Abstract

Melatonin, the main secretory product of the pineal gland, inhibits the growth of several types of cancer cells. Melatonin limits human prostate cancer cell growth by a mechanism which involves the regulation of androgen receptor function but it is not clear whether other mechanisms may also be involved. Time-course and dose-dependent studies were performed using androgen-dependent (LNCaP) and independent (PC3) prostate cancer cells. Cell number, cell viability, and cell cycle progression were studied. Neuroendocrine differentiation of these cells was evaluated by studying morphological and biochemical markers. Finally, molecular mechanisms including the participation of melatonin membrane receptors, intracellular cAMP levels, and the PKA signal transduction pathway were also analyzed. Melatonin treatment dramatically reduced the number of prostate cancer cells and stopped cell cycle progression in both LNCaP and PC3 cells. In addition, it induced cellular differentiation as indicated by obvious morphological changes and neuroendocrine biochemical parameters. The role of melatonin in cellular proliferation and differentiation of prostate cancer cells is not mediated by its membrane receptors nor related to PKA activation. The t...Continue Reading

References

Mar 1, 1992·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·R J Reiter
Sep 1, 1991·British Journal of Urology·R J CohenZ Haffejee
Dec 6, 1995·Journal of the National Cancer Institute·E GiovannucciW C Willett
Feb 1, 1995·Trends in Pharmacological Sciences·M L Dubocovich
Jun 7, 1994·Proceedings of the National Academy of Sciences of the United States of America·Y J BangJ B Trepel
Jan 1, 1996·The Prostate. Supplement·P A Abrahamsson
Jan 1, 1997·CA: a Cancer Journal for Clinicians·S L ParkerP A Wingo
Apr 1, 1997·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·D RaghavanM Javle
Sep 16, 1998·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·M L DubocovichM I Masana
Apr 24, 1999·The Journal of Steroid Biochemistry and Molecular Biology·Z Lupowitz, N Zisapel
Apr 30, 1999·The Prostate·P A Abrahamsson
May 26, 1999·Journal of Pineal Research·E GiladN Zisapel
Jul 21, 1999·Journal of the National Cancer Institute·M O RippleR Weindruch
Oct 2, 2001·CA: a Cancer Journal for Clinicians·R T GreenleeM Thun
Dec 18, 2002·Journal of Pineal Research·M AllegraM A Livrea
Feb 28, 2003·Free Radical Research·Russel J ReiterSilvia Lopez-Burillo
Mar 5, 2003·Biochemical and Biophysical Research Communications·Rosa M SainzRussel J Reiter
Mar 12, 2003·Life Sciences·Paula A Witt-EnderbyMelissa A Melan
Mar 15, 2003·Clinica Chimica Acta; International Journal of Clinical Chemistry·Monte S Willis, Frank H Wians
Jul 5, 2003·Scandinavian Journal of Urology and Nephrology. Supplementum·Jens Hansson, Per-Anders Abrahamsson
Aug 2, 2003·British Journal of Pharmacology·Stephen T O'RourkePaul M Vanhoutte
Dec 17, 2003·Journal of Pineal Research·Carmen RodriguezRussel J Reiter

❮ Previous
Next ❯

Citations

Apr 13, 2010·Analytical and Bioanalytical Chemistry·D HeviaR M Sainz
Feb 6, 2009·Expert Reviews in Molecular Medicine·Stephen G GrantPaula A Witt-Enderby
Mar 31, 2007·Reproduction, Fertility, and Development·B Díaz López, L Debeljuk
May 9, 2012·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Lara G SigurdardottirLorelei A Mucci
Nov 30, 2006·Indian Journal of Medical Sciences·T RavindraY R Ahuja
Feb 18, 2014·Micron : the International Research and Review Journal for Microscopy·Ana Paula C BatistaEliete C Silva
Aug 3, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Wootae KimJa-Eun Kim
Sep 26, 2012·Cellular and Molecular Life Sciences : CMLS·Sara ProiettiMariano Bizzarri
Dec 4, 2009·American Journal of Translational Research·Yin SunJiaoti Huang
Sep 6, 2011·Molecular and Cellular Endocrinology·Dave LanoixCathy Vaillancourt
Nov 26, 2015·International Journal of Pharmaceutics·Bedriye TopalMenemşe Gümüşderelioğlu
Jun 10, 2009·International Journal of Cancer. Journal International Du Cancer·Isabel QuirósJuan C Mayo
Jun 26, 2009·Journal of Pineal Research·O RögelspergerT Thalhammer
Aug 2, 2006·Journal of Pineal Research·Guillermo García-SantosCarmen Rodriguez
Feb 9, 2007·Journal of Pineal Research·Sara RubioJosé Quintana
May 13, 2010·Journal of Pineal Research·Javier CabreraJosé Quintana
Jul 16, 2010·Journal of Pineal Research·Anna Leja-SzpakRussel J Reiter
Mar 19, 2011·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Hui LiuRui-Xiang Zhou
Apr 9, 2013·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Li XuRui-Xiang Zhou
Dec 14, 2011·Journal of Pineal Research·Virginia Alvarez-GarcíaSamuel Cos
Jul 2, 2011·Journal of Pineal Research·Alicia GonzálezSamuel Cos
Jan 23, 2015·Journal of Pineal Research·David HeviaRosa M Sainz

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.