PMID: 8609593Aug 1, 1995Paper

Melatonin reduces the severity of dextran-induced colitis in mice

Journal of Pineal Research
P T Pentney, G A Bubenik

Abstract

Melatonin administration reduces the severity of dextran sodium sulphate (DSS)-induced colitis in mice. After 7 weeks of daily intraperitoneal melatonin administration (150 micrograms/kg), rectal bleeding and occult blood was eliminated in all mice in which colitis was induced by DSS. In addition the frequency and severity of focal lesions in the mucosa was dramatically reduced. Furthermore, weight loss and higher food consumption observed in DSS-treated mice was reversed in DSS-treated mice injected with melatonin. All treated groups exhibited significant alterations in goblet cell distribution as a result of DSS or melatonin administration. Surprisingly, serum melatonin levels were more than 10 times higher in mice that received DSS as compared to controls. The significant improvement in the conditions of melatonin-treated mice might be due to its effect on the smooth muscles of the colon, the blood supply in the mucosa, its capability as an antioxidant and scavenger of free radicals, or its effect on the immune system of the gut. The higher plasma levels of melatonin in DSS-treated mice might be due to a stress-induced increase in the production of gastrointestinal (GIT) melatonin.

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Citations

Jul 16, 2008·Inflammatory Bowel Diseases·Paul D TerryShanti V Sitaraman
Mar 15, 2006·Digestive Diseases and Sciences·Hulya OzturkAli Kemal Uzunlar
Apr 15, 2006·Digestive Diseases and Sciences·Ali CetinkayaYakup Gumusalan
Jan 7, 1999·European Journal of Pharmacology·G CostantinoA P Caputi
May 5, 2001·Physiology & Behavior·M L PinillosM J Delgado
Nov 15, 2001·General Pharmacology·V Nosál'ováV Bauer
Jan 16, 1999·Free Radical Biology & Medicine·F AntunesF Xi
Nov 24, 1999·Drugs in R&D
Aug 30, 2011·Journal of Gastroenterology and Hepatology·Hongjie ZhangRuihua Shi
May 13, 2005·The Tohoku Journal of Experimental Medicine·Ali CetinkayaMehmet Akif Buyukbese
Feb 2, 2008·World Journal of Gastroenterology : WJG·Alper AkcanYucel Aritas
Oct 26, 2011·World Journal of Gastroenterology : WJG·Chun-Qiu ChenMartin Storr
Oct 25, 2007·Digestive Diseases and Sciences·Rauf Onur EkCigdem Yenisey
Aug 1, 1997·Journal of Pineal Research·D P CardinaliA I Esquifino
Dec 24, 1997·Journal of Pineal Research·B D Callaghan
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Jun 4, 2013·International Journal of Molecular Sciences·Gu-Jiun LinHuey-Kang Sytwu
Nov 20, 2013·Inflammatory Bowel Diseases·Gopabandhu Jena, Priyanka P Trivedi

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