Melatonin regulates the rhythmic migration of neutrophils in live zebrafish

Journal of Pineal Research
Da-long RenBing Hu

Abstract

The circadian clock plays a vital role in physiology and behavior such as the sleep-wake cycle and blood pressure and hormone levels. Immune responses also display circadian rhythmicity and particularly pineal melatonin contributes to immunological processes. Little attention, however, is given to mechanisms underlying rhythmic neutrophil responses to the injury. Here, we used a transgenic Tg(lyz:EGFP) zebrafish tail fin transection model to investigate whether the recruitment of neutrophils toward the injured site is regulated by the circadian clock. We found that migrating neutrophils display robust rhythmicity, peaking at darkness. Melatonin positively regulates rhythmic neutrophil migration, as evidenced that treatment with melatonin at low dosage can significantly enhance neutrophil recruitment toward the injured site, which is attenuated by luzindole treatment and in pinealectomized fish. Furthermore, using a transgenic zebrafish eyeball model, we observed that melatonin enhances secretion of two cytokines, TNF-α and IL-8, both of which markedly enhance neutrophil migration. Taken together, these results highlight a positive role of melatonin in rhythmic neutrophil migration and help obtain a better understanding of circa...Continue Reading

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Citations

Aug 26, 2015·The Journal of Endocrinology·Da-Long RenBing Hu
May 2, 2016·Brain, Behavior, and Immunity·Krisztina EllaKrisztina Káldi
Jun 8, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Roberto ZivieriNicola Pacini
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Oct 16, 2018·Journal of Experimental Zoology. Part A, Ecological and Integrative Physiology·María S GastónMarcos Vaira
Nov 22, 2017·Chronobiology International·Ke NieBing Hu
Mar 30, 2018·Frontiers in Behavioral Neuroscience·Deng-Feng HuangBing Hu
Apr 6, 2019·Frontiers in Cellular and Infection Microbiology·Juliane Cristina Ribeiro FernandesSandra Marcia Muxel
Mar 21, 2021·Fish & Shellfish Immunology·Sébastien BaekelandtPatrick Kestemont
Aug 26, 2021·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·R S MatosV M S Bruin

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