Melatonin reverses the expression of morphine-induced conditioned place preference through its receptors within central nervous system in mice

European Journal of Pharmacology
Jing HanYi-Ming Wei

Abstract

A growing body of evidence indicates the prominent actions of melatonin on the opioidergic system. Nevertheless, effect of melatonin on rewarding properties of morphine is still obscure. In particular, effect of melatonin on the expression of morphine reward is unknown. We evaluated the effect of exogenous administration of melatonin on the expression of morphine reward in mice using a conditioned place preference (CPP) paradigm. The conditioned place preference was induced by morphine (s.c., 3 mg/kg, once each day for 5 consecutive days) in mice. Our data showed that the intraperitoneal (i.p.) administration of melatonin (12.5-50 mg/kg) reversed the expression of morphine-induced conditioned place preference in a dose-dependent manner. Furthermore, the intracerebroventricular (i.c.v.) administration of melatonin (0.125-0.5 mg/kg) also resulted in dose-dependent reversal effect on the expression of morphine-induced conditioned place preference. We further investigated which of melatonin receptor subtypes within the central nervous system was mediating this reversal action in mice using luzindole (2-benzyl-N-acetyltryptamine, a non-selective antagonist for melatonin MT1 and MT2 receptors) and K185 (N-butanoyl-2-(5,6,7-trihydro-1...Continue Reading

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