PMID: 11339508May 8, 2001Paper

Melatonin stimulates glutathione peroxidase activity in human chorion

Journal of Pineal Research
Y OkataniT Fukaya

Abstract

In preeclampsia, placental production of lipid peroxides is abnormally increased, while placental glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) activities are decreased. Administration of melatonin, a powerful scavenger of oxygen free radicals, also may protect the placenta from free radical-induced damage by increasing the activity of antioxidant enzymes. To test this hypothesis we administered melatonin to pregnant women before they underwent voluntary interruption of pregnancy between 7 and 9 wk of gestation. Melatonin (6 mg) was administered orally at 12:00 hr, and samples of chorion and maternal blood were obtained at the time of the procedure, 1, 2 or 3 hr later. We measured the melatonin concentration in maternal serum and activities of GSH-Px and SOD and levels of melatonin in chorionic homogenates. Melatonin administration was reflected by markedly increased melatonin concentrations in maternal serum and in chorion, with peak levels achieved 1 hr after melatonin administration (serum, 46.87 +/- 10.87 nM/L; chorionic homogenate, 4.36 +/- 1.56 pmol/mg protein). Between 1 and 3 hr after melatonin administration, GSH-Px activity in chorionic homogenates increased significantly (P < 0.001), with peak levels...Continue Reading

Citations

Jul 3, 2013·Nature Reviews. Drug Discovery·Everett J ModingDavid G Kirsch
Apr 5, 2005·Clinical Obstetrics and Gynecology·Joseph A Spinnato, Jeffery C Livingston
Jul 20, 2005·Clinical and Experimental Pharmacology & Physiology·Burhanettin Baydas, Ismail Meral
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May 2, 2002·Journal of Pineal Research·Göksel SenerGül Ayanoglu-Dulger
Mar 1, 2012·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Yu-Chieh ChenLi-Tung Huang
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