Melatonin suppresses lung cancer metastasis by inhibition of epithelial-mesenchymal transition through targeting to Twist

Clinical Science
Chia-Chia ChaoChih-Hsin Tang

Abstract

The epithelial-mesenchymal transition (EMT) phenotype, whereby mature epithelial cells undergo phenotype transition and differentiate into motile, invasive cells, has been indicated in tumor metastasis. The melatonin hormone secreted by the pineal gland has an antioxidant effect and protects cells against carcinogenic substances that reduce tumor progression. However, the effects of melatonin in EMT and lung cancer metastasis are largely unknown. We found that melatonin down-regulated EMT by inhibiting Twist/Twist1 (twist family bHLH transcription factor 1) expression. This effect was mediated by MT1 receptor, PLC, p38/ERK and β-catenin signaling cascades. Twist expression was positively correlated with tumor stage and negatively correlated with MT1 expression in lung cancer specimens. Furthermore, melatonin inhibited EMT marker expression and lung cancer metastasis to liver in vivo Finally, melatonin shows promise in the treatment of lung cancer metastasis and deserves further study.

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Citations

Jul 10, 2019·International Journal of Molecular Sciences·Po-Chun ChenChih-Hsin Tang
Aug 28, 2019·Molecular and Cellular Biochemistry·Sankha BhattacharyaSanjay Singh
May 2, 2018·Current Medicinal Chemistry·Geir BjorklundSalvatore Chirumbolo
Oct 2, 2019·International Journal of Molecular Sciences·Sevindzh KletukhinaMarina Gomzikova
Dec 1, 2020·Journal of Cellular Physiology·Shih-Wei WangShiou-Sheng Chen
Mar 30, 2021·OncoTargets and Therapy·Sangiliyandi GurunathanJin-Hoi Kim
Nov 14, 2020·Genome Biology·Luis Enrique Cortés-HernándezCatherine Alix-Panabières
May 1, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Wamidh H TalibAsma Ismail Mahmod
Aug 17, 2021·Clinical and Experimental Pharmacology & Physiology·Preeyaporn Plaimee PhiboonchaiyananPiyarat Govitrapong

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