Melatonin, thymic serum factor, and cortisol levels in healthy subjects of different age and patients with skin melanoma

Journal of Pineal Research
Y A Grinevich, I F Labunetz

Abstract

Results are given of daily excretion levels of 6-oxymelatonin, thymic serum factor (FTS), and cortisol in the blood of 140 healthy subjects and 90 patients with skin melanoma, ranging from 20 to 49 years of age. Correlation factor (eta) was used for evaluating the correlation between the indices examined. Daily excretion of 6-oxymelatonin was found to decrease considerably in healthy men over 30 years of age, the extent of such reduction correlating with age (eta = 0.48 +/- 0.19, P less than 0.02). Similar correlation is absent in healthy women. There is an age-related reduction in FTS in both healthy women (eta = 0.63 +/- 0.13, P less than 0.001) and men (eta = 0.57 +/- 0.12 P less than 0.001), although in the latter this reduction occurs 10 years earlier (beginning at 30 years) and is more pronounced. Blood cortisol levels in healthy subjects increase with age, more notably in men than in women. Age-related changes in the content of the hormones under study are still more pronounced when patients of corresponding age groups develop neoplasms. Male patients from 20 to 29 and 30 to 49 years of age with melanoma show daily levels of 6-oxymelatonin excretion of 10.13 +/- 0.71 micrograms/24 hr and 11.70 +/- 1.26 micrograms/24 hr, ...Continue Reading

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