Melatonin treatment alters glucosensing capacity and mRNA expression levels of peptides related to food intake control in rainbow trout hypothalamus

General and Comparative Endocrinology
Marta Conde-SieiraJesús M Míguez

Abstract

As demonstrated in previous studies, the functioning of brain glucosensing systems in rainbow trout is altered under stress conditions in a way that they are unable to respond properly to changes in glucose levels. Melatonin has been postulated as necessary for homeostatic control of energy metabolism in several vertebrate groups, and in fish it has been suggested as an anti-stress molecule. To evaluate the possible effects of melatonin on glucosensing, we have incubated hypothalamus and hindbrains of rainbow trout at different glucose concentrations in the presence of increased doses (0.01, 1, and 100nM) of melatonin assessing whether or not the responses to changes in glucose levels of parameters related to glucosensing (glucose, glycogen and glucose 6-phosphate levels, activities of GK, GSase and PK, and mRNA content of GK, GLUT2, Kir6.x-like, and SUR-like) are modified in the presence of melatonin. While no effects of melatonin were observed in hindbrain, in hypothalamus melatonin treatment up-regulated glucosensing parameters, especially under hypo- and normo-glycaemic conditions. The effects of melatonin in hypothalamus occurred apparently through MT(1) receptors since most effects were counteracted by the presence of luz...Continue Reading

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Citations

Jul 19, 2015·Developmental and Comparative Immunology·Magdalena KepkaMagdalena Chadzinska
May 21, 2013·Zebrafish·Chiara Carla PiccinettiOliana Carnevali
Mar 3, 2018·Hormone Molecular Biology and Clinical Investigation·Abdulkerim Kasım Baltaci, Rasim Mogulkoc
Jan 24, 2017·Frontiers in Neuroscience·Marta Conde-Sieira, José L Soengas
Mar 27, 2021·Journal of Neuroendocrinology·Laura Gabriela NisembaumJack Falcón
Jun 5, 2012·The Journal of Experimental Biology·Marta Conde-SieiraJosé L Soengas

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