Melatonin treatment in the prevention of postoperative delirium in cardiac surgery patients

Kardiochirurgia i torakochirurgia polska = Polish journal of cardio-thoracic surgery
Panagiotis ArtemiouAdrian Kolesar

Abstract

Post-cardiac surgery delirium is a severe complication. The circadian rhythm of melatonin secretion has been shown to be altered postoperatively. It was hypothesized that restoring normal sleeping patterns with a substance that is capable of resynchronizing circadian rhythm such as exogenous administration of melatonin may possibly reduce the incidence of postoperative delirium. This paper represents a prospective clinical observational study. Two consecutive groups of 250 consecutive patients took part in the study. Group A was the control group and group B was the melatonin group. In group B, the patients received prophylactic melatonin treatment. The main objectives were to observe the incidence of delirium, to identify any predictors of delirium, and to compare the two groups based on the delirium incidence. The incidence of delirium was 8.4% in the melatonin group vs. 20.8% in the control group (p = 0.001). Predictors of delirium in the melatonin group were age (p = 0.001) and higher EuroSCORE II value (p = 0.001). In multivariate analysis, age and EuroSCORE II value (p = 0.014) were predictors of postoperative delirium. Comparing the groups, the main predictors of delirium were age (p = 0.001), EuroSCORE II value (p = 0.0...Continue Reading

Associated Clinical Trials

Citations

Aug 20, 2016·The Annals of Pharmacotherapy·Cheri K Walker, Mark A Gales
Oct 9, 2019·Journal of the American Geriatrics Society·Andrew H FordOsvaldo P Almeida
Jan 30, 2018·Frontiers in Medicine·Sin Wei ChoyChris Moran

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BETA
sedation
coronary artery bypass

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SPSS

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