Melatonin's Antineoplastic Potential Against Glioblastoma.

Cells
Enrico MorettiRita Rezzani

Abstract

Glioblastoma (GBM) is one of the most intransigent and aggressive brain tumors, and its treatment is extremely challenging and ineffective. To improve patients' expectancy and quality of life, new therapeutic approaches were investigated. Melatonin is an endogenous indoleamine with an incredible variety of properties. Due to evidence demonstrating melatonin's activity against several cancer hallmarks, there is growing interest in its use for preventing and treating cancer. In this review, we report on the potential effects of melatonin, alone or in combination with anticancer drugs, against GBM. We also summarize melatonin targets and/or the intracellular pathways involved. Moreover, we describe melatonin's epigenetic activity responsible for its antineoplastic effects. To date, there are too few clinical studies (involving a small number of patients) investigating the antineoplastic effects of melatonin against GBM. Nevertheless, these studies described improvement of GBM patients' quality of life and did not show significant adverse effects. In this review, we also report on studies regarding melatonin-like molecules with the tumor-suppressive properties of melatonin together with implemented pharmacokinetics. Melatonin effec...Continue Reading

References

Sep 1, 1991·Journal of the American Podiatric Medical Association·R H DavisD P Murdoch
May 1, 1988·Journal of Ethnopharmacology·L A HartR P Labadie
Apr 30, 1999·Science·S Artavanis-TsakonasR J Lake
Jun 7, 2000·Proceedings of the National Academy of Sciences of the United States of America·M GromeierE Wimmer
Jul 7, 2000·Journal of Clinical Pharmacology·R L DeMuroJ S Bertino
Nov 15, 2000·American Journal of Physiology. Lung Cellular and Molecular Physiology·V J Thannickal, B L Fanburg
Nov 2, 2001·Nature·T ReyaI L Weissman
Feb 28, 2002·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·P Lissoni
Mar 13, 2002·American Journal of Clinical Pathology·Maria-Chiara OsterheldCharlotte Fontolliet
Mar 20, 2002·Current Topics in Medicinal Chemistry·Darío Acuña CastroviejoRussel J Reiter
Mar 21, 2002·Nature Reviews. Cancer·Michael M GottesmanSusan E Bates
May 23, 2002·Biochimie·Andrew P HalestrapSamantha J Clarke
Sep 11, 2002·American Journal of Clinical Pathology·Dionne C DillonHarold L Asch
Oct 3, 2002·Neuro-oncology·Margaret WrenschMitchel S Berger
Oct 25, 2002·The Journal of Pharmacy and Pharmacology·Russel J ReiterSilvia Lopez-Burillo
Mar 11, 2003·Nucleic Acids Research·Tanfis Istiaq AlamDongchon Kang
Mar 12, 2003·Life Sciences·Paula A Witt-EnderbyMelissa A Melan
Sep 6, 2003·Frontiers in Bioscience : a Journal and Virtual Library·Margarita L DubocovichMonica I Masana
Dec 25, 2004·Journal of Pineal Research·Josefa LeónRussel J Reiter
Mar 11, 2005·The New England Journal of Medicine·Roger StuppUNKNOWN National Cancer Institute of Canada Clinical Trials Group
Aug 16, 2005·Journal of Pineal Research·Cristina Tomás-Zapico, Ana Coto-Montes
Dec 8, 2005·CNS Drugs·Adam McGechan, Keri Wellington
Feb 15, 2007·International Journal of Clinical Practice·A Altun, B Ugur-Altun
Jun 20, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Kathryn A CarsonEdward G Shaw
Jul 3, 2007·Journal of Neuro-oncology·Paul R van GinkelDaniel M Albert
Mar 28, 2008·Cell Research·Jinbo Yang, George R Stark
Mar 29, 2008·Arzneimittel-Forschung·Rüdiger HardelandDaniel P Cardinali
Apr 19, 2008·Cold Spring Harbor Symposia on Quantitative Biology·A J Lewy
Jul 2, 2008·Breast Cancer Research and Treatment·Ahmet KorkmazRussel J Reiter
Aug 30, 2008·Drugs·Dene Simpson, Monique P Curran
Apr 8, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Pamela J Goodwin
Jun 26, 2009·Journal of Pineal Research·Ignacio BejaranoAna B Rodríguez
Jul 2, 2009·Advances in Therapy·Seithikurippu R Pandi-PerumalDaniel P Cardinali
Jul 16, 2009·Current Vascular Pharmacology·Alberto Dominguez-RodriguezRussel J Reiter
Sep 18, 2009·Journal of Cellular Biochemistry·Candace A Gilbert, Alonzo H Ross
Apr 13, 2010·Analytical and Bioanalytical Chemistry·D HeviaR M Sainz
Jun 11, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Francesca LuchettiFrancesco Galli
Jul 31, 2010·The American Journal of Pathology·Eli E BarCharles G Eberhart

❮ Previous
Next ❯

Citations

Oct 2, 2020·Analytical Methods : Advancing Methods and Applications·Min HuangTian'an Jiang
Jun 18, 2020·Cancers·Sangiliyandi GurunathanJin-Hoi Kim
Dec 23, 2020·Epigenomics·Mohammad Hossein PourhanifehAzam Hosseinzadeh
Jan 21, 2021·International Journal of Molecular Sciences·Russel J ReiterSergio Rosales-Corral
Mar 7, 2021·Biomolecules·Jocelyn M BretonDaniela Kaufer
May 1, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Wamidh H TalibAsma Ismail Mahmod
May 12, 2021·Life Sciences·Russel J ReiterLuiz Gustavo de Almeida Chuffa

❮ Previous
Next ❯

Methods Mentioned

BETA
surgical resection

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Pineal Research
A Panzer, M Viljoen
Frontiers in Pharmacology
Gaia FaveroRita Rezzani
Reviews in the Neurosciences
Sayantan MaitraSubhrajit Bhattacharya
© 2021 Meta ULC. All rights reserved