Melatonin's role in preventing toxin-related and sepsis-mediated hepatic damage: A review

Pharmacological Research : the Official Journal of the Italian Pharmacological Society
Eduardo Esteban-ZuberoRussel J Reiter

Abstract

The liver is a central organ in detoxifying molecules and would otherwise cause molecular damage throughout the organism. Numerous toxic agents including aflatoxin, heavy metals, nicotine, carbon tetrachloride, thioacetamide, and toxins derived during septic processes, generate reactive oxygen species followed by molecular damage to lipids, proteins and DNA, which culminates in hepatic cell death. As a result, the identification of protective agents capable of ameliorating the damage at the cellular level is an urgent need. Melatonin is a powerful endogenous antioxidant produced by the pineal gland and a variety of other organs and many studies confirm its benefits against oxidative stress including lipid peroxidation, protein mutilation and molecular degeneration in various organs, including the liver. Recent studies confirm the benefits of melatonin in reducing the cellular damage generated as a result of the metabolism of toxic agents. These protective effects are apparent when melatonin is given as a sole therapy or in conjunction with other potentially protective agents. This review summarizes the published reports that document melatonin's ability to protect hepatocytes from molecular damage due to a wide variety of subst...Continue Reading

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Citations

Aug 25, 2016·International Journal of Molecular Sciences·Jiunn-Ming SheenLi-Tung Huang
Jan 19, 2017·Journal of Pineal Research·Zhengwang CaoZhou Zhou
Mar 3, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Russel J ReiterBing Xu
Aug 9, 2017·Cellular and Molecular Life Sciences : CMLS·Darío Acuña-CastroviejoGermaine Escames
Nov 11, 2017·Inflammation·Amanda Della GiustinaFabricia Petronilho
Aug 9, 2016·Journal of Pineal Research·Russel J ReiterLilian Qin
Sep 12, 2019·American Journal of Physiology. Gastrointestinal and Liver Physiology·Leonardo BaiocchiGianfranco Alpini
Nov 7, 2017·International Journal of Endocrinology·Gaia FaveroRita Rezzani
Jun 21, 2017·BioMed Research International·Cezary ChojnackiJan Chojnacki

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