MELDB: a database for microbial esterases and lipases

FEBS Letters
Ho-Young KangCheol-Goo Hur

Abstract

MELDB is a comprehensive protein database of microbial esterases and lipases which are hydrolytic enzymes important in the modern industry. Proteins in MELDB are clustered into groups according to their sequence similarities based on a local pairwise alignment algorithm and a graph clustering algorithm (TribeMCL). This differs from traditional approaches that use global pairwise alignment and joining methods. Our procedure was able to reduce the noise caused by dubious alignment in the distantly related or unrelated regions in the sequences. In the database, 883 esterase and lipase sequences derived from microbial sources are deposited and conserved parts of each protein are identified. HMM profiles of each cluster were generated to classify unknown sequences. Contents of the database can be keyword-searched and query sequences can be aligned to sequence profiles and sequences themselves.

References

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Citations

Jul 27, 2010·Interdisciplinary Sciences, Computational Life Sciences·Saravanan ParameswaranSanjukta Patra
May 6, 2011·Acta Crystallographica. Section F, Structural Biology and Crystallization Communications·Heejin HwangT Doohun Kim
Jun 23, 2009·Extremophiles : Life Under Extreme Conditions·Mark LevissonServé W M Kengen
Jun 24, 2008·Biotechnology Advances·Babu JosephGeorge Thomas
Oct 26, 2016·Protein Science : a Publication of the Protein Society·Yingfei ChenPeter J Reilly
May 1, 2008·Biotechnology Journal·Haeyoung JeongJihyun F Kim

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