PMID: 8581421Apr 1, 1995Paper

Meliavolkenin, a new bioactive triterpenoid from Melia volkensii (Meliaceae)

Bioorganic & Medicinal Chemistry
L ZengJ L McLaughlin

Abstract

Meliavolkenin, a new triterpene with an apotirucallane skeleton, has been isolated from the root bark of Melia volkensii (Meliaceae) by bioactivity-directed fractionation using the brine shrimp lethality test. The structure has been elucidated using spectral and chemical data. The relative stereochemistries were determined by reduction and acetonide derivations, and the ring conformations were analyzed using the results of NOESY experiments. Meliavolkenin was bioactive in the brine shrimp lethality test and gave moderate cytotoxicities against three human solid tumor lines.

References

Jul 15, 1975·International Journal of Cancer. Journal International Du Cancer·F Vánky Stjernswärd
Nov 1, 1991·Journal of Natural Products·J M SaadP E Fanwick

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Citations

Jun 19, 2012·Natural Product Research·Preecha PhuwapraisirisanPongpun Siripong
Jan 5, 2011·Frontiers in Bioscience (Landmark Edition)·Anupam BishayeeMarjorie Perloff
Oct 11, 2012·Journal of Enzyme Inhibition and Medicinal Chemistry·Nighat Sultana, Zafar Saeed Saify
Apr 17, 2010·Chemistry & Biodiversity·Lei ZhaoQing-Wen Shi
Apr 28, 1999·Journal of Natural Products·C L CantrellN H Fischer
Feb 14, 1998·Journal of Natural Products·L L RogersJ L McLaughlin

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