Melinjo seed extract increases adiponectin multimerization in physiological and pathological conditions.

Scientific Reports
Kentaro OnikiTsuyoshi Shuto

Abstract

Melinjo seed extract (MSE) contains large amounts of polyphenols, including dimers of trans-resveratrol (e.g. gnetin C, L, gnemonoside A, B and D), and has been shown to potentially improve obesity. However, there is no clinical evidence regarding the anti-obesity effects of MSE, and its mechanisms are also unclear. We investigated the hypothesis that MSE supplementation increases the adiponectin (APN) multimerization via the up-regulation of disulfide bond A oxidoreductase-like protein (DsbA-L) under either or both physiological and obese conditions. To investigate the effect of MSE on the physiological condition, 42 healthy young volunteers were enrolled in a randomized, double-blind placebo-controlled clinical trial for 14 days. The participants were randomly assigned to the MSE 150 mg/day, MSE 300 mg/day or placebo groups. Furthermore, in order to investigate the effect of MSE on APN levels under obese conditions, we administered MSE powder (500 or 1000 mg/kg/day) to control-diet- or high-fat-diet (HFD)-fed C57BL/6 mice for 4 weeks. All participants completed the clinical trial. The administration of MSE 300 mg/day was associated with an increase in the ratio of HMW/total APN in relation to the genes regulating APN multimer...Continue Reading

References

Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
May 23, 2002·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Tomoya HayashiSeiichi Era
Nov 18, 2008·Proceedings of the National Academy of Sciences of the United States of America·Meilian LiuFeng Liu
Feb 19, 2009·Journal of Agricultural and Food Chemistry·Eishin KatoFujio Sakan
Apr 29, 2009·Clinica Chimica Acta; International Journal of Clinical Chemistry·Kae-Woei LiangWayne H-H Sheu
Jul 13, 2011·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·James M SmoligaJoseph A Baur
Jun 7, 2013·Molecular Nutrition & Food Research·Charles-Henry CottartJean-Louis Beaudeux
Jul 19, 2013·Journal of Natural Products·Hidetaka OtaYasuyoshi Ouchi
Jan 15, 2014·Best Practice & Research. Clinical Endocrinology & Metabolism·Meilian Liu, Feng Liu
Jan 24, 2014·Evidence-based Complementary and Alternative Medicine : ECAM·Hiroyuki KonnoTakuji Shirasawa
Sep 23, 2014·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Yun-Qian ZhangLai Jiang
Jan 28, 2015·Ageing Research Reviews·Marta G NovelleRafael de Cabo
Mar 20, 2016·Cardiovascular Diabetology·Charlotte BoydensJohan Van de Voorde
Mar 25, 2016·Psychiatry Research·Kentaro OnikiNorio Yasui-Furukori
Feb 25, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Hongzhi ChenFeng Liu
Aug 19, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Awais WahabJianxin Chen
Nov 1, 2017·Proceedings of the National Academy of Sciences of the United States of America·Juli BaiFeng Liu
Feb 5, 2019·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Mathias PlauthStephan C Bischoff

❮ Previous
Next ❯

Methods Mentioned

BETA
enzyme-linked immunosorbent assay

Software Mentioned

SPSS
Power
SPSS Amos
StepOnePlus Real - Time PCR system

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.