Melioidosis in children: a retrospective study

International Journal of Dermatology
Yee-Wah FoongMark Jean-Aan Koh

Abstract

Melioidosis, caused by Burkholderia pseudomallei, is endemic in Singapore and can present as localized or disseminated disease. Demographic data, clinical features, investigation results, treatments, and outcomes in patients aged <16 years diagnosed with melioidosis at KK Women's and Children's Hospital between January 2002 and January 2014 were retrospectively reviewed. Data for patients with primary skin disease and those with other organ involvement were compared. Seventeen children were diagnosed with melioidosis. Their median age was 12.5 years (range: 2-15 years). Nine (53%) patients presented with localized cutaneous melioidosis and five (29%) with localized lymphadenitis, pneumonia, or septic arthritis. The remaining three (18%) patients had melioidosis sepsis; two of these patients died from septic shock. Treatment included an initial 1-2 weeks of IV antibiotics followed by 3-6 months of oral combination antibiotics. All cases of localized cutaneous disease resolved completely with no recurrences. Three (60%) of the five patients with localized involvement of other organ systems achieved complete resolution of disease, and the remaining two were lost from follow-up. Although uncommon, melioidosis can occur in children ...Continue Reading

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Citations

Aug 16, 2015·Transactions of the Royal Society of Tropical Medicine and Hygiene·Yao FangXu-Hu Mao
May 11, 2016·The American Journal of Tropical Medicine and Hygiene·Yao FangXuhu Mao
Oct 3, 2018·Tropical Medicine and Infectious Disease·Siew Hoon SimGladys Gek Yen Tan
Nov 23, 2016·BMC Infectious Diseases·Paul TurnerDavid A B Dance

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