PMID: 18208738Jan 23, 2008Paper

Melkersson-Rosenthal syndrome treated with clofazimine

Ugeskrift for laeger
Anette Bygum, Marie Toft-Petersen

Abstract

Melkersson-Rosenthal syndrome (MRS) is a triad of facial palsy, lingua plicata and chronic orofacial swelling. Mono- and oligosymptomatic forms are common and cheilitis granulomatosa is often considered a monosymptomatic form of MRS. In advanced stages the histological findings are noncaseating granulomas. The etiology remains unclear and treatment is difficult. A few uncontrolled studies have shown corticosteroids and clofazimine to be effective. We report on a 31 year-old man with complete MRS who responded well to treatment with clofazimine.

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